000			02928cam a2200325 a 4500
003			EG-GiCUC
008			180218s2017 ua d f m 000 0 eng d
040			_aEG-GiCUC _beng _cEG-GiCUC
041	0		_aeng
049			_aDeposite
097			_aM.Sc
099			_aCai01.08.03.M.Sc.2017.Ze.A
100	0		_aZeinab Mohammed Goda
245	1	0	_aAnalytical study of some nitrogen containing active pharmaceutical ingredients / _cZeinab Mohammed Goda ; Supervised Mostafa Abdelaty , Mohamed Refaat Elghobashy , Yasmin Mohammed Fayez
246	1	5	_aدراسة تحليلية لبعض الأدوية المحتوية على مركبات نيتروجينية فعالة
260			_aCairo : _bZeinab Mohammed Goda , _c2017
300			_a228 P. : _bcharts ; _c25cm
502			_aThesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Analytical Chemistry
520			_aThis work is concerned with the quantitative determination of some mixtures of drugs containing nitrogen including; Diflucortolone Valerate (DIF) in its mixture with Isoconazole Nitrate (ISO), Paracetamol (PAR) in its mixture with Phenylephrine hydrochloride and Cetirizine dihydrochloride. In this thesis; different analytical techniques were adopted, namely, spectrophotometric, UV-chemometric, liquid chromatographic and electrochemical methods for the determination of the previously mentioned compounds in their pure powder, laboratory prepared mixtures and dosage forms. In part I; General introduction and literature review of DIF and ISO were described. This part described also the quantitative determination of DIF and ISO in their combination either in pure form or dosage form using spectrophotometry including four methods (constant center spectrophotometric method (CC), ratio difference (RD), the first derivative of the ratio spectra (¹DD) and mean centering of ratio spectra (MC)), TLC-Densitometry and HPLC methods. In part II; General introduction and literature review of PAR, PHE and CTZ were described. Then different analytical methods were described for the determination of the studied drugs in their combination either in pure form or dosage form including spectrophotometry (The first method is successive spectrophotometric resolution technique (SSRT), the second method is the mean centering of ratio spectra (MC) and the third method is the first derivative of the ratio spectra- zero crossing (¹DD)), UV-Chemometry, TLC-Densitometry, MLC and potentiometric determination of CTZ using ions selective electrodes
530			_aIssued also as CD
653		4	_aDiflucortolone Valerate (DIF)
653		4	_aIsoconazole Nitrate (ISO)
653		4	_aParacetamol (PAR)
700	0		_aMohamed Refaat Elghobashy , _eSupervisor
700	0		_aMostafa Abdelaty , _eSupervisor
700	0		_aYasmin Mohammed Fayez , _eSupervisor
905			_aNazla _eRevisor
905			_aShimaa _eCataloger
942			_2ddc _cTH
999			_c65058 _d65058