000			03536cam a2200349 a 4500
003			EG-GiCUC
005			20250223031931.0
008			180219s2017 ua dh f m 000 0 eng d
040			_aEG-GiCUC _beng _cEG-GiCUC
041	0		_aeng
049			_aDeposite
097			_aM.Sc
099			_aCai01.11.28.M.Sc.2017.Na.R
100	0		_aNashwa Sayed Abdelhameed Abdelmegeed
245	1	0	_aRight ventricular function and pulmonary artery pressure in juvenile Systemic Lupus Erythematous with or without positive anticardiolipin Antibodies and their correlation to disease activity / _cNashwa Sayed Abdelhameed Abdelmegeed ; Supervised Samia Salah Eldin Mahmoud , Huda Marzouk Mohamed , Doaa Mohamed Abdelaziz
246	1	5	_aتحديد ارتفاع ضغط الشريان الرئوي و الخلل الوظيفي للبطين الايمن في حالات الذئبة الحمراء المصحوبة او غير المصحوبة بارتفاع الاجسام المضادة و علاقتها بنشاط المرض
260			_aCairo : _bNashwa Sayed Abdelhameed Abdelmegeed , _c2017
300			_a112 P. : _bcharts , facsimiles ; _c25cm
502			_aThesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Pediatrics
520			_aCardiovascular disease is a major cause of death in patients with systemic lupus erythematosus (SLE), especially during the late phase of the disease. Ventricular dysfunction is considered one of its common findings with overt morbidity and mortality. There is also some evidence about the association of antiphospholipid (aPL) antibodies with ventricular dysfunction in children with SLE and also there is a correlation between the activity of the disease and right ventricular dysfunction. This study aimed at evaluating the prevalence of echocardiographically documented systolic and diastolic right ventricular dysfunction in patients with SLE with or without anti-phospholipid antibodies, and to examine whether these antibodies are associated with right ventriclar dysfunction independently of valvular abnormalities and to evaluate the association of the disease activity with right ventricular function. Tissue Doppler echocardiography was performed on 30 patients with SLE whether they had antiphospholipid syndrome or not ,anticardiolipin antibodies was done to all patients and repeated after 6 weeks in positive cases and The disease activity using SLEDAI-2K score was done for all patients at the time of the study .Another 30 normal volunteer patients were taken as matched controls. 16 patients (53.3 %) had positive antiphospholipid antibodies, of whom 9 (30%) had positive aCL IgM, 7 (23.3%) had positive aCL IgG. 8 patients of those with positive APL antibodies had clinical evidence suggestive of antiphospholipid syndrome.The mean of the disease activity of all patients measured at the time of the study was 22 patients with venous manifestations of APS have higher SLEDAI score than patients with absent manifestations. No significant increase of pulmonary artery pressure in secondary antiphospholipid syndrome patients
530			_aIssued also as CD
653		4	_aRight ventricular function
653		4	_aSLEDAI-2K
653		4	_aSystemic Lupus Erythematosus
700	0		_aDoaa Mohamed Abdelaziz , _eSupervisor
700	0		_aHuda Marzouk Mohamed , _eSupervisor
700	0		_aSamia Salah Eldin Mahmoud , _eSupervisor
856			_uhttp://172.23.153.220/th.pdf
905			_aEnas _eCataloger
905			_aNazla _eRevisor
942			_2ddc _cTH
999			_c65086 _d65086