000			02990cam a2200337 a 4500
003			EG-GiCUC
005			20250223031935.0
008			180227s2017 ua dh f m 000 0 eng d
040			_aEG-GiCUC _beng _cEG-GiCUC
041	0		_aeng
049			_aDeposite
097			_aM.Sc
099			_aCai01.11.25.M.Sc.2017.No.P
100	0		_aNour Muhammad Ibrahim
245	1	0	_aPrevention of post-traumatic osteoarthritis after intra-articular knee fractures using biological therapies / _cNour Muhammad Ibrahim ; Supervsed Khaled Fawzy M. Abdelkader , Ahmed Maher Sultan
246	1	5	_aالوقاية من خشونة المفاصل ما بعد الكسور المفصلية بإستخدام العلاجات البيولوجية
260			_aCairo : _bNour Muhammad Ibrahim , _c2017
300			_a118 P. : _bcharts , facsimiles ; _c25cm
502			_aThesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Orthopedic Surgery
520			_aIntroduction: Post-traumatic osteoarthritis is a degenerative disease of articular joints that results in the irreversible destruction of hyaline cartilage. Through persistent pain and eventual loss of joint function, advanced PTOA reduces quality of life and places the patient at greater risk for the development of comorbidities. A promising route of drug administration during the early phase after joint injury is intra-articular injection. Aim of study: The aim of this study is to evaluate the clinical effectiveness of intra-articular injection of Hyaluronic acid into the knee joint with intra-articular fracture in prevention of posttraumatic osteoarthritis. Materials and methods: This prospective case-control study involved 40 patients (20 in each group) with intra-articular knee fracture .They were treated in the hospital and evaluated after 18 months. 20 patients were injected with three intra-articular Hyaluronic acid injections at weekly interval starting immediately after surgery and 20 patients without injection. Patients presented to the emergency department of Cairo University Hospitals between the periods from November 2015 to April 2017. Results: The results showed Patients treated with intra-articular Hyaluronic acid injection after fixation had significantly less pain (KOOS) (P = 0.001). No significant difference was found between both groups in other symptoms, complications, functional outcome or quality of life. Conclusion: Our study supports a direct role for Hyaluronic acid in the acute phase of the inflammatory process that follows articular injury and provides initial evidence of efficacy for IA HA
530			_aIssued also as CD
653		4	_aHyaluronic acid
653		4	_aIntra-articular
653		4	_aPost-traumatic osteoarthritis
700	0		_aAhmed Maher Sultan , _eSupervisor
700	0		_aKhaled Fawzy M. Abdelkader , _eSupervisor
856			_uhttp://172.23.153.220/th.pdf
905			_aNazla _eRevisor
905			_aShimaa _eCataloger
942			_2ddc _cTH
999			_c65202 _d65202