000			02835cam a2200349 a 4500
003			EG-GiCUC
005			20250223031941.0
008			180310s2017 ua dh f m 000 0 eng d
040			_aEG-GiCUC _beng _cEG-GiCUC
041	0		_aeng
049			_aDeposite
097			_aM.Sc
099			_aCai01.11.28.M.Sc.2017.Mo.P
100	0		_aMohamed Samy Abdeljffar
245	1	0	_aPost renal transplant rejection in Cairo university children`s hospital : _btypes, course & outcome / _cMohamed Samy Abdeljffar ; Supervised Bahia Hasan Mostafa , Sahar Shaker Sheta , Doaa Mohamed Salah
246	1	5	_aالأنواع والمسارات والمالآت لحالات رفض الزرع الكلوي في مستشفي الأطفال - جامعة القاهرة
260			_aCairo : _bMohamed Samy Abdeljffar , _c2017
300			_a192 P. : _bcharts , facsimiles ; _c25cm
502			_aThesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Pediatrics
520			_aIntroduction: Allograft rejection is a serious obstacle that should be tackled promptly for good graft outcome. Objective: The aim of this study was to investigate kidney rejection among renal transplant recipients being followed up in Kidney Transplantation Outpatient Clinic, Cairo University Children`s Hospital (CUCH) through years 2009-2017. Study design: Observational study involved 100 pediatric kidney recipients. Results: 24% developed at least one rejection episodes, 8% developed recurrent rejections. A total of 38 rejection episodes observed. Allograft biopsy showed 47.4% borderline changes, 26.3% AMR, 23.7% CMR & 2.6% mixed rejection. Pulse steroid used in 71.1%, ATG in 36.8%, plasma exchange and IVIG in 34.2% of rejection episodes. Response showed complete recovery in 39.5%, partial recovery in 47.4% and worsening creatinine in 13.2%. Mortality affected 6% mainly sepsis related, while graft failure affected 3%. Unrelated donor & non-compliance were associated with rejection (p<0.001 and p=0.002 respectively). 81% used CsA initially, 45% didn{u2019}t change their protocol, 71% used FK506 as a current protocol. Conclusion: donor source and immunosuppressive non-compliance were significant factors for developing kidney rejection, BPAR was correlated to low current eGFR. Single episodes carried better pathology (early changes) and better outcome, while rejection recurrence carried worse prognosis and poor response to antirejection therapy
530			_aIssued also as CD
653		4	_aAllograft
653		4	_aBiopsy
653		4	_aRejection
700	0		_aBahia Hasan Mostafa , _eSupervisor
700	0		_aDoaa Mohamed Salah , _eSupervisor
700	0		_aSahar Shaker Sheta , _eSupervisor
856			_uhttp://172.23.153.220/th.pdf
905			_aNazla _eRevisor
905			_aShimaa _eCataloger
942			_2ddc _cTH
999			_c65369 _d65369