000			03084cam a2200325 a 4500
003			EG-GiCUC
008			180310s2017 ua dh f m 000 0 eng d
040			_aEG-GiCUC _beng _cEG-GiCUC
041	0		_aeng
049			_aDeposite
097			_aM.Sc
099			_aCai01.11.32.M.Sc.2017.No.R
100	0		_aNouran Ibrahim Mahmoud Ali
245	1	0	_aRheumatoid arthritis activity and severity in relation to commonly used contraception methods in a cohort of Egyptian female patients / _cNouran Ibrahim Mahmoud Ali ; Supervised Hatem Hamdi Eleishi , Hala Lotfy Fayed , Heba Ahmed Kamal
246	1	5	_aدراسة نشاط و شدة مرض الروماتويد المفصلي الرثوي و علاقتهما بوسائل منع الحمل المستخدمة في مجموعة من السيدات المصريات
260			_aCairo : _bNouran Ibrahim Mahmoud Ali , _c2017
300			_a114 P. : _bcharts , facsimiles ; _c25cm
502			_aThesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Rheumatology and Rehabilitation
520			_aObjective: The study was conducted to evaluate the associations between the use of commonly used contraceptive methods and rheumatoid arthritis (RA) disease activity and severity in a cohort of Egyptian female RA patients. Methods: Two hundred enrolled patients were divided into two groups; non-contraception users (50 patient) and contraception users (150 patients). The latter group was further subdivided into 89 patients who were intrauterine device (IUD) users, 45 oral contraceptives (OC) users and 16 injectables users. All patients underwent assessment by routine laboratory tests, Rheumatoid factor (RF) and antibodies to citrullinated protein antigens (ACPA). RA disease activity was assessed using DAS28/CRP while disease severity was assessed by using RASS. Bilateral hand x-rays were done and interpreted by the Short Erosion Scale (SES). Results: There was significantly higher ACPA titer among IUD users (p < 0.05), as well as, a longer disease duration compared to other methods users. The RASS was greater in injectables users (p < 0.01) in comparison to other methods users, but there was no significant differences regarding DAS28/CRP or SES between different contraceptive methods users. Additionally, total leucocyte count was higher in OC users compared to other methods (p < 0.05). Conclusion: There is an increased risk of ACPA positivity in women who are currently IUD users and an increased severity measured by the RASS among injectable users. However, there is no relation between RA activity and the currently used contraceptive methods. Mechanisms by which IUD could increase risk for RA-related autoimmunity need further study
530			_aIssued also as CD
653		4	_aContraception
653		4	_aDAS28/CRP
653		4	_aRheumatoid Arthritis
700	0		_aHala Lotfy Fayed , _eSupervisor
700	0		_aHatem Hamdi Eleishi , _eSupervisor
700	0		_aHeba Ahmed Kamal , _eSupervisor
905			_aNazla _eRevisor
905			_aShimaa _eCataloger
942			_2ddc _cTH
999			_c65371 _d65371