000			02978cam a2200325 a 4500
003			EG-GiCUC
008			180318s2016 ua dh f m 000 0 eng d
040			_aEG-GiCUC _beng _cEG-GiCUC
041	0		_aeng
049			_aDeposite
097			_aM.Sc
099			_aCai01.19.05.M.Sc.2016.Mo.O
100	0		_aMohamed Magdy Mahmoud
245	1	0	_aOutcome of children with acute lymphoblastic leukemia treated without cranial irradiation at National Cancer Institute, Egypt / _cMohamed Magdy Mahmoud ; Supervised Iman Abdelmokhales Sidhom , Amr Abdalla Salem , Omnia Kamal Elgebaly
246	1	5	_aنتائج علاج الأطفال المصابين باللوكيميا الليمفاوية الحادة بدون العلاج الإشعاعى الدماغى بالمعهد القومى للأورام
260			_aCairo : _bMohamed Magdy Mahmoud , _c2016
300			_a135 P. : _bcharts , facsimiles ; _c25cm
502			_aThesis (M.Sc.) - Cairo University - National Cancer Institute - Department of Pediatric Oncology
520			_aThis retrospective study included children between 1 and 18 years of age with confirmed diagnosis of acute lymphoblastic leukemia who started treatment at the National Cancer Institute, Cairo University during the period from 1st January 2010 to 31st December 2012 and they were followed up till the end of September 2016. B-cell precursor phenotype was encountered in 78.6% ofpatients, T-cell in 21.4%. According to study XV of SJCRH criteria for risk classification, 38.5% of patients were in the low risk group and 61.5% were in the standard/high risk group. At the end of the induction phase, 49 patients (26.9%) died and the remaining 133 patients (73.1%) achieved remission. The 5 years overall survival and event free survival for all 182 patients were 52% and 51.6% respectively, while the 5 years disease free survival for evaluable 133 patients at end of inducation was 72.3%. In the current study, 9 patients had initially CNS III status, only one of them had isolated CNS relapse and none of these patients received cranial irradiation as first line. In this study, we had 10 CNS relapses out of 133 evaluable patients at end of induction (7.52%), 8 were isolated CNS relapse, while 2 were combined CNS and medullary relapse. As for for prognostic factors for any CNS relapse, risk stratification was the only significant variable. The commulative incidence of any CNS relapse was 0.8%, 5.8%, 8% and 10% at 1,2,3 and 5 years respectively while the commulative incidence of isolated CNS relapse was 0.8%, 4.9%, 7% and 8.9% at 1,2,3 and 5 years respectively
530			_aIssued also as CD
653		4	_aAcute lymphoblastic leukemia
653		4	_aChildren
653		4	_aOutcome
700	0		_aAmr Abdalla Salem , _eSupervisor
700	0		_aIman Abdelmokhales Sidhom , _eSupervisor
700	0		_aOmnia Kamal Elgebaly , _eSupervisor
905			_aNazla _eRevisor
905			_aShimaa _eCataloger
942			_2ddc _cTH
999			_c65482 _d65482