000			03348cam a2200349 a 4500
003			EG-GiCUC
005			20250223031947.0
008			180324s2017 ua d f m 000 0 eng d
040			_aEG-GiCUC _beng _cEG-GiCUC
041	0		_aeng
049			_aDeposite
097			_aM.Sc
099			_aCai01.11.23.M.Sc.2017.Mo.T
100	0		_aMohamed Ahmed Mortada Elsharief
245	1	0	_aTreatment outcome & prognostic factors of parameningeal rhabdomyosarcoma treated at NCI between 2005 and 2014 / _cMohamed Ahmed Mortada Elsharief ; Supervised Amr Sakr , Ehab Khalil , Reem Emad
246	1	5	_aنتائج العلاج و العوامل المؤثرة لحالات الأورام الغرنية بالعضلات المخططة الجارسحائية و التي تم علاجها بمعهد الأورام في الفترة من 2005 {u2013} 2014
260			_aCairo : _bMohamed Ahmed Mortada Elsharief , _c2017
300			_a99 P. : _bcharts ; _c25cm
502			_aThesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Oncology (Clinical)
520			_aStudy purpose and objectives: To assess local control rate and calculate the overall survival (OS) and progression free survival (PFS) of pediatric PM RMS patients treated at NCI between 2005 and 2014 and to examine the possible prognostic factors affecting treatment outcome. Materials and Methods: A retrospective study in which medical records of 44 patients newly diagnosed with PM RMS treated at NCI between 2005 and 2014 at Radiation Oncology department, National Cancer Institute, Cairo University, were reviewed. The rate of local control was determined as well as the overall survival and the progression free survival. Prognostic factors and their effect on survival were studied. Results: Median age was 7 years (range: 1 to 20 years). Male to female ratio was 1.9:1. The commonest primary subsite was nasopharynx (29.6%) followed by maxilla (20.5%) and infratemporal fossa (18.2%). Embryonal RMS was the most common pathological subtype (63.6%). Intracranial extension (ICE) was reported in 31.8% of cases. IRSG stage 3 constituted 75% of cases. All patients were treated by systemic CTH (VAC) then RTH was adopted at week 0 {u2013} 4 in case of ICE and at week 12 in the absence of this risk factor. Radiotherapy was the local treatment modality in 39 cases and 2 patients underwent surgery followed by radiotherapy postoperatively while 2 patients underwent surgery only and one patient died due to disease progression after receiving induction chemotherapy. Median RTH dose was 5040 cGy and median overall treatment period (OAP) was 47 days. Complete response was reported in 75% of cases. The 5 year OS and PFS rates were 50% and 43.8% respectively. Factors which affected survival included age at diagnosis, T stage, pretreatment Hemoglobin %, ICE, OAP and treatment response at week 40 on univariate analysis while on multivariate analysis only OAP and treatment response affected survival
530			_aIssued also as CD
653		4	_aNCI
653		4	_aParameningeal
653		4	_aRMS
700	0		_aAmr Sakr , _eSupervisor
700	0		_aEhab Khalil , _eSupervisor
700	0		_aReem Emad , _eSupervisor
856			_uhttp://172.23.153.220/th.pdf
905			_aNazla _eRevisor
905			_aShimaa _eCataloger
942			_2ddc _cTH
999			_c65558 _d65558