000			03051cam a2200349 a 4500
003			EG-GiCUC
005			20250223031947.0
008			180325s2017 ua dh f m 000 0 eng d
040			_aEG-GiCUC _beng _cEG-GiCUC
041	0		_aeng
049			_aDeposite
097			_aM.Sc
099			_aCai01.11.28.M.Sc.2017.Ra.E
100	0		_aRahma Adel Hussein Eltanany
245	1	0	_aEffects of obesity on health-related quality of life in juvenile-onset systemic lupus erythematsous / _cRahma Adel Hussein Eltanany ; Supervised Heba Taher Osman , Eman Taher Elkordy , Sarah Ali Zenhom Mohamed
246	1	5	_aآثار السمنة على جودة الحياه المرتبطه بالصحة لدى الأطفال المصابين بمرض الذئبه الحمراء
260			_aCairo : _bRahma Adelhussein Eltanany , _c2017
300			_a138 P. : _bcharts , fcsimiles ; _c25cm
502			_aThesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Pediatrics
520			_aBack ground: Juvenile onset systemic lupus erythematosus (JSLE) is an autoimmune disease with multi organs affection character, it almost associated with auto-antibodies formation. JSLE patients are treated with corticosteroids more frequent than adults making them more liable for being obese. Objective: Evaluating the effects of obesity on health-related quality of life (HRQOL) measures in Juvenile-onset SLE (JSLE). Methods: This study included 104 JSLE patients and 104 apparently healthy children as controls, both were collected from Rheumatology and collagen vascular diseases clinic at Cairo University specialized children's' hospital and outpatients clinic at Abo El-Reesh El-Mounira children's' hospital respectively. Both groups are subjected to full history taking, anthropometric measurements; defying obese patient with BMI more than 95th centile. In a secondary analysis, the domain and summary scores of pediatric quality of life Rheumatology module (PedsQL-RM) of obese jSLE patients were compared to those of non-obese jSLE patients as well as historical obese and non-obese healthy controls. Mixed-effects modeling were performed to evaluate the relationship between obesity and HRQOL measures. Results: Among 104 JSLE patients, 34.5% (n=36) were obese. Obesity had a significant negative impact on HRQOL in JSLE. Obese JSLE patients had lower score in all domains of HRQOL compared to non-obese JSLE patients, and to non-obese and obese healthy controls Conclusion: Our study demonstrated the negative impact of obesity on patient-reported outcomes in JSLE. This supports the importance of weight management for the therapeutic plan of JSLE
530			_aIssued also as CD
653		4	_aChildren
653		4	_aObesity
653		4	_aSLE
700	0		_aEman Taher Elkordy , _eSupervisor
700	0		_aHeba Taher Osman , _eSupervisor
700	0		_aSarah Ali Zenhom Mohamed , _eSupervisor
856			_uhttp://172.23.153.220/th.pdf
905			_aNazla _eRevisor
905			_aShimaa _eCataloger
942			_2ddc _cTH
999			_c65577 _d65577