000			03269cam a2200349 a 4500
003			EG-GiCUC
005			20250223031949.0
008			180321s2017 ua dh f m 000 0 eng d
040			_aEG-GiCUC _beng _cEG-GiCUC
041	0		_aeng
049			_aDeposite
097			_aM.Sc
099			_aCai01.11.28.M.Sc.2017.Ol.I
100	0		_aOla Soliman Emam Younis
245	1	0	_aIncidence of viral respiratory pathogens causing exacerbations in cystic fibrosis patients / _cOla Soliman Emam Younis ; Supervised Mona Mohsen Elattar , Dina Hossam Eldine Hamed , Mai Mohamed Alsherif
246	1	5	_aنسبة تواجد الفيروسات التنفسية اثناء تفاقم حالات التليف الكيسي
260			_aCairo : _bOla Soliman Emam Younis , _c2017
300			_a114 P. : _bcharts , facsimiles ; _c25cm
502			_aThesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Pediatrics
520			_aBackground: Cystic fibrosis is a genetic disease characterized by progressive epithelial secretory gland dysfunction associated with repeated respiratory infections. Although bacteria have historically been considered to play a major role in cystic fibrosis (CF) airway damage, a strong impact of respiratory viral infections is also now recognized. Emerging evidence confirms that respiratory viruses are associated with exacerbation and facilitation of bacterial colonization in CF patients. Methods: This is a cross sectional observational study recruiting 60 patients diagnosed as CF. Following in CF clinic, Children{u2019}s Hospital, Cairo University, throughout a period of 7 months. Their age ranged from 6 months to 13 years. Children had nasal swabs and sputum samples obtained during pulmonary exacerbations. Multiplex PCR technique was used to detect respiratory viruses from nasal swabs. Results: We detected viruses in 48 patients during exacerbation (80%), the most common virus was Rhinovirus 43.4% present in all seasons, followed by bocavirus 20%, adenovirus 13.3%, enterovirus 10%, HMPV 6.7%. Co infection with double viruses was found in 10 patients. While bacteria present in 56.7% of patients and the most common organism found was pseudomonas spp in 20% of patients then staph aeurus, MRSA, Klebsiella and Hemophilus influenza. Positive CRP was detected in 53.3% of patients.There was significant correlation between positive bacterial culture and and certain viruses as influenza A virus, Enterovirus, HMPV with P value ( {u02C2}0.01, 0.002, 0.002 respectively).There was significant relation between both influenza A virus and Enterovirus with the need for oxygen with p value ( 0.004, 0.02 respectively).There was no significant relation between viruses and the need for ICU admission .There was significant correlation between HMPV and seasonal variation with (p value 0.001)
530			_aIssued also as CD
653		4	_aCystic fibrosis
653		4	_aExacerbation
653		4	_aRespiratory viruses
700	0		_aDina Hossam El Dine Hamed , _eSupervisor
700	0		_aMai Mohamed Al Sherif , _eSupervisor
700	0		_aMona Mohsen El Attar , _eSupervisor
856			_uhttp://172.23.153.220/th.pdf
905			_aNazla _eRevisor
905			_aShimaa _eCataloger
942			_2ddc _cTH
999			_c65639 _d65639