000			03589cam a2200325 a 4500
003			EG-GiCUC
008			180407s2017 ua dh f m 000 0 eng d
040			_aEG-GiCUC _beng _cEG-GiCUC
041	0		_aeng
049			_aDeposite
097			_aM.Sc
099			_aCai01.11.04.M.Sc.2017.Ab.V
100	0		_aAbdo Naji Ahmed Mahmood
245	1	4	_aThe value of platelet to lymphocyte ratio and neutrophil to lymphocyte ratio in predicting in-hospital morbidity and mortality among infective endocarditis patients / _cAbdo Naji Ahmed Mahmood ; Supervised Wael Mohamed Elnaggar , Marwa Sayed Abdo Mashaal , Ahmed Mohamed Eldamaty
246	1	5	_aأهمية نسبة الصفائح الدموية الى الخلايا الليمفاوية ونسبة الخلايا المعتدلة الى الخلايا الليمفا وية في التنبؤ بمعدل حدوث الوفاة والمضاعفات داخل المستشفى بين مرضى التهاب شغاف القلب الانتاني (الميكروبي
260			_aCairo : _bAbdo Naji Ahmed Mahmood , _c2017
300			_a134 P. : _bcharts , facsimiles ; _c25cm
502			_aThesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Cardiology
520			_aBackground:Early and accurate risk prediction is an important clinical demand in patients with infective endocarditis (IE). The platelet-to-lymphocyte ratio (PLR) and the neutrophil-to-lymphocyte ratio (NLR) are an independent predictors of worse prognosis in both infectious and cardiovascular disease. Very limited number of studies were conducted to evaluate the prognostic role of these markers in infective endocarditis. The aim of this study was to determine the value of PLR and NLR in the prediction of in-hospital morbidity and mortality among IE patients. Methods:We analyzed clinical, laboratory,echocardiographic data and the clinical course throughout the whole period ofin-hospital stayin a total of 142 consecutive patients with definite IE diagnosis.PLR and NLR were obtained directly from the complete blood count picture taken upon the admission of the patients. Results: The in-hospital mortality, central nervous system, fulminant sepsis, acute heart failure, acute renal failure and embolization to different vital organs complications had occurred in [30 (21%), 38(27%), 34 (24%), 32 (22.5%), 40 (28%) and 90 (63.4%) ] patients respectively. Higher NLR, total leucocytic count, neutrophils percentage, level of creatinine and C-reactive protein(CRP)obtained upon admission were significantly higher in the in-hospital mortality group [p=<0.001, p=0.008, p=0.001, p=0.004 and p=0.036 respectively]; also lower lymphocyte (percentage and count), lower platelet count, presence of multiple valve involvement, presence of severe acute aortic valve regurge and infection by organism like MRSA or candida albican were significantly associated with higher in-hospital mortality rate [ p=(<0.001 and 0.015), p=0.001, p=0.014, p=0.007 and 0.030 or 0.028 respectively. Higher NLR was significantly associated with higher incidence of fulminant sepsis and major arterial embolization in IE patients [p=0.001 and p=0.028 respectively]
530			_aIssued also as CD
653		4	_aInfective endocarditis
653		4	_aNeutrophil to lymphocyte ratio
653		4	_aPlatelet to lymphocyte ratio
700	0		_aAhmed Mohamed Eldamaty , _eSupervisor
700	0		_aMarwa Sayed Abdo Mashaa , _eSupervisor
700	0		_aWael Mohamed Elnaggar , _eSupervisor
905			_aNazla _eRevisor
905			_aShimaa _eCataloger
942			_2ddc _cTH
999			_c65771 _d65771