000			03098cam a2200349 a 4500
003			EG-GiCUC
005			20250223031955.0
008			180414s2017 ua dh f m 000 0 eng d
040			_aEG-GiCUC _beng _cEG-GiCUC
041	0		_aeng
049			_aDeposite
097			_aM.Sc
099			_aCai01.11.28.M.Sc.2017.Am.V
100	0		_aAmira Ahmed Elrefaee Abass Khalil
245	1	0	_aVitamin D status in Egyptian sickle cell disease patients and its correlation to the course of the disease / _cAmira Ahmed Elrefaee Abass Khalil ; Supervised Mona Mohamed Hamdy , Niveen Mohamed Salama , Ghada Maher Mohamed
246	1	5	_aمعدل فيتامين(د) عند مرضي أنيميا الخلايا المنجلية وتأثيره علي مسار المرض
260			_aCairo : _bAmira Ahmed Elrefaee Abass Khalil , _c2017
300			_a131 P. : _bcharts , facsimiles ; _c25cm
502			_aThesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Pediatrics
520			_aBackground: Vitamin D insufficiency (VDD) is an established phenomenon in patients with sickle cell disease (SCD). Although a large portion of the population has been described as having low levels of vitamin D, individuals with SCD are at higher risk for VDD than their health counterparts. Despite these findings, its relationship with SCD is unclear and vitamin D levels are not routinely checked or treated in patients with SCD. Methods: Vitamin D levels (25-OHD) were measured in eighty SCD patients who were in steady state and sixty age and sex matched healthy controls using enzyme linked immunosorbent assay (ELISA). Comparison between two SCD patients groups one with VDD and other group with normal 25-OHD level was done focusing on medical history including vaos-occlusive crisis and transfusion history Hematological profile and biomarker of hemolysis (hemoglobin [Hb]/hematocrit, reticulocyte percentage and lactate dehydrogenase [LDH] levels) were done. Results: Assessment of 25-OHD levels revealed that 60% of patient group had VDD compared to 26.7% in control group with significance difference between the two groups who had VDD that mean serum level of 25- OHD was 9.9 ±2.1 ng/mL and 11 ± 1.8 ng/mL, respectively. There was significant negative correlation between serum 25-OHD level and age, frequency of VOC, reticulocyte count, LDH and AST (hemolysis biomarkers) while there is positive correlations with hemoglobin, hematocrite and age of first blood transfusion. Significant differences were found between patients with VDD and patients with normal 25-OHD in frequency of hospital admission, recurrent infections, frequency of blood transfusion
530			_aIssued also as CD
653		4	_aEgyptian sickle cell disease
653		4	_aVitamin D
653		4	_aVitamin D insufficiency (VDD)
700	0		_aGhada Maher Mohamed , _eSupervisor
700	0		_aMona Mohamed Hamdy , _eSupervisor
700	0		_aNiveen Mohamed Salama , _eSupervisor
856			_uhttp://172.23.153.220/th.pdf
905			_aNazla _eRevisor
905			_aShimaa _eCataloger
942			_2ddc _cTH
999			_c65847 _d65847