000			02943cam a2200349 a 4500
003			EG-GiCUC
005			20250223031958.0
008			180418s2017 ua dh f m 000 0 eng d
040			_aEG-GiCUC _beng _cEG-GiCUC
041	0		_aeng
049			_aDeposite
097			_aM.Sc
099			_aCai01.08.01.M.Sc.2017.Ta.B
100	0		_aTamer Youssry Mahmoud
245	1	0	_aBiochemical study on the role of propolis in experimental schistosomiasis / _cTamer Youssry Mahmoud ; Supervised Amira Abdelmonem Shaheen , Sherine Maher Risk , Amany Sayed Maghraby
246	1	5	_aدراسة كيموحيوية علي تأثير صمغ عسل النحل في البلهارسيا التجربية
260			_aCairo : _bTamer Youssry Mahmoud , _c2017
300			_a161 P. : _bcharts , facsimiles ; _c25cm
502			_aThesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Biochemistry
520			_aDespite the wide currently use of praziquantel (PZQ) in treatment of schistosomiasis, low cure rates have been recorded in many studies. The aim of this study was directed to evaluate the curative effect of propolis (Pp) alone or in combination with PZQ on biochemical, immunological, parasitological and histological changes associated with experimental schistosomiasis in mice. Methods: Schistosomamansoni infected mice were divided into 2 experimental sets, each of 4 subgroups: (i) untreated, (ii) treatedwith Pp/day p.ofor 4 weeks, iii) treated with PZQ p.o 2X 500mg/kg bd wt, and (iv) treated with Pp + PZQ as in group ii and iii; all treatment started on the 8th week post infection, in addition to uninfected group as control for the previous groups. Results: Treatment of infected mice with Pp although failed to eradicate the worm, it significantly reduced the hepatic granuloma number, their lymphocytic infiltration and aggregation, hepatic and splenic myeloperoxidase (MPO) activity and plasma, liver and thymus nitric oxide (NOx) levels together with normalization of plasma proteins and alleviation of oxidative stress in the examined tissues as evidenced by reduction of malondialdehyde (MDA) and normalization of glutathione (GSH). Promising results were obtained when Pp given in combination with PZQ, where the anti-schistosomal activity of PZQ was markedly potentiated with complete alleviation and amelioration of the histological and biochemical alteration associated with schistosomiasis. Conclusion: this study highlights the potential usefulness of Pp as an adjunct to PZQ in schistosomiasis
530			_aIssued also as CD
653		4	_aPraziquantel
653		4	_aPropolis
653		4	_aSchistosomiasis
700	0		_aAmany Sayed Maghraby , _eSupervisor
700	0		_aAmira Abdelmonem Shaheen , _eSupervisor
700	0		_aSherine Maher Risk , _eSupervisor
856			_uhttp://172.23.153.220/th.pdf
905			_aNazla _eRevisor
905			_aShimaa _eCataloger
942			_2ddc _cTH
999			_c65932 _d65932