| 000 | 02840cam a2200349 a 4500 | ||
|---|---|---|---|
| 003 | EG-GiCUC | ||
| 005 | 20250223032005.0 | ||
| 008 | 180512s2017 ua dh f m 000 0 eng d | ||
| 040 |
_aEG-GiCUC _beng _cEG-GiCUC |
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| 041 | 0 | _aeng | |
| 049 | _aDeposite | ||
| 097 | _aPh.D | ||
| 099 | _aCai01.11.07.Ph.D.2017.Ri.C | ||
| 100 | 0 | _aRiham Ali Gad | |
| 245 | 1 | 0 |
_aChromosome 20q deletion as a structural aberration in philadelphia positive-chronic myeloid leukemia / _cRiham Ali Gad ; Supervised Hala Mohamed Farawila , Hamdi Mohamed Zawam , Manal M. Mahmoud Makhlouf |
| 246 | 1 | 5 | _aمحو كروموزوم 20 كيو كخلل شكلي في مرضي فيلادلفيا موجب سرطان الدم الميلودي المزمن |
| 260 |
_aCairo : _bRiham Ali Gad , _c2017 |
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| 300 |
_a161 P. : _bcharts , facsimiles ; _c25cm |
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| 502 | _aThesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Clinical and Chemical Pathology | ||
| 520 | _aIn Philadelphia-positive CML, abnormalities of chromosome 20 were detected, which were associated, in the majority of cases, with clonal evolution and disease progression to accelerated phase or blastic crisis.Our work aimed to study the prevalence of chromosome 20q aberrations in an Egyptian cohort ofPh-positive CML and to evaluate the correlation of these genetic defects with the clinical presentation, laboratory data, disease progression and evolution into accelerated phase or blastic crisis, treatment outcome as well as overall survival. FISH technique was used to detect abnormalities of chromosome 20qin thirty philadelphia-positive CML patients and fifteen age and sex matched normal healthy individuals as a control group. Our study revealed that 14/30Ph-positive CML patients (47%) had aberrations of chromosome 20q. Nine of the thirty patients (30%) had del 20q12. Trisomy 20q was found in 5/30 patients (17%). These cytogenetic abnormalities were associated with significant increased risk of the evolution phase in CML and had a significant shorter total free survival and overall survival as well as a highly significant higher incidence of unfavorable treatment outcome in all phases. In conclusion, these genomic aberrations of chromosome 20q can play an important role in the pathophysiology, development, clinical presentation, laboratory data, disease progression and treatment outcome as well as overall survival in Ph-positive CML patients | ||
| 530 | _aIssued also as CD | ||
| 653 | 4 | _a20q12 deletion | |
| 653 | 4 | _aFISH | |
| 653 | 4 | _aPh-positive CML | |
| 700 | 0 |
_aHala Mohamed Farawila , _eSupervisor |
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| 700 | 0 |
_aHamdi Mohamed Zawam , _eSupervisor |
|
| 700 | 0 |
_aManal M. Mahmoud Makhlouf , _eSupervisor |
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| 856 | _uhttp://172.23.153.220/th.pdf | ||
| 905 |
_aNazla _eRevisor |
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| 905 |
_aShimaa _eCataloger |
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| 942 |
_2ddc _cTH |
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| 999 |
_c66181 _d66181 |
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