000 02887cam a2200337 a 4500
003 EG-GiCUC
005 20250223032005.0
008 180512s2017 ua f m 000 0 eng d
040 _aEG-GiCUC
_beng
_cEG-GiCUC
041 0 _aeng
049 _aDeposite
097 _aM.Sc
099 _aCai01.12.02.M.Sc.2017.Na.S
100 0 _aNada Sabry Ibraheem Abdelhady
245 1 0 _aSynthesis and biological evaluation of novel heterocyclic compounds as antimicrobial and/or anticancer agents /
_cNada Sabry Ibraheem Abdelhady ; Supervised Ismail Abdelshafy Abdelhamid , Magda Fikry Mahmoud Mohamed
246 1 5 _aالتحضير و التقييم البيولوجى لمركبات غير متجانسة الحلقة الجديدة كمضادات للميكروبات و/ أو مضادات للسرطان
260 _aCairo :
_bNada Sabry Ibraheem Abdelhady ,
_c2017
300 _a122 P. ;
_c25cm
502 _aThesis (M.Sc.) - Cairo University - Faculty of Science - Department of Biochemistry
520 _aNovel bis (1,4-dihydropyridine) derivatives linked to aliphatic or aromatic core via ester as well as ether linkages7-16 were prepared, and confirmed by several spectral tools. The prepared compounds showed better cytotoxicity results against A549 than MCF7. The computational studies showed that compound 9 is binding to xIAP and cIAP1 with good energy score. With respect to the antibacterial activity, compound 14 exhibit the most efficiency one against the studied bacterial strains and hence it is used in the docking study on Ý-ketoacyl-ACP synthaseIII (fabH). The results showed good interaction of compound 14 with fabH. Four compounds were chosen for molecular studies on A549 cell line. The molecular data showed that all compounds caused cell cycle arrest at G1 phase and slightly increased the percentage of early apoptosis with no detectable DNA ladder characteristic of apoptotic cell death. The four compounds induced the up regulation of Bax gene and the down regulation of P53and Bcl2 genes. The activity of caspase 3 was slightly higher than control for compounds 10 and 16 and slightly lower than control for compounds 11 and 15. We also studied the effect of compound 11 on normal cell line (HFB4) after it's treatment with genotoxic factor (H₂ O₂) and we noticed that compound 11 reduces DNA damaging effect of H₂ O₂. So, the new compounds have limited side effects on normal cells and could be used as complementary drugs to reduce the harmful effects of other chemotherapeutic agent
530 _aIssued also as CD
653 4 _aA549
653 4 _aBis 1,4-dihydropyridine
653 4 _aMCF7
700 0 _aIsmail Abdelshafy Abdelhamid ,
_eSupervisor
700 0 _aMagda Fikry Mahmoud Mohamed ,
_eSupervisor
856 _uhttp://172.23.153.220/th.pdf
905 _aNazla
_eRevisor
905 _aSamia
_eCataloger
942 _2ddc
_cTH
999 _c66182
_d66182