| 000 | 02733cam a2200325 a 4500 | ||
|---|---|---|---|
| 003 | EG-GiCUC | ||
| 008 | 180515s2017 ua d f m 000 0 eng d | ||
| 040 |
_aEG-GiCUC _beng _cEG-GiCUC |
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| 041 | 0 | _aeng | |
| 049 | _aDeposite | ||
| 097 | _aM.Sc | ||
| 099 | _aCai01.08.05.M.Sc.2017.Na.D | ||
| 100 | 0 | _aNaira Ahmed Farid Mohammed | |
| 245 | 1 | 0 |
_aDevelopment and validation of analytical methods for the determination of some drugs affecting blood coagulation / _cNaira Ahmed Farid Mohammed ; Supervised Ramzia Ismail Ibrahim Elbagary , Nadia Fayek Youssef , Ehab Farouk Hassan Elkady |
| 246 | 1 | 5 | _aتطويرِ و تقييمِ طرق تحليليةِ لتقديرِ بعضِ الأدويةِ المؤثرة علىِ تجلط الدم |
| 260 |
_aCairo : _bNaira Ahmed Farid Mohammed , _c2017 |
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| 300 |
_a220 P. : _bcharts ; _c25cm |
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| 502 | _aThesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutical Chemistry | ||
| 520 | _aThe health and the safety of pharmaceutical products consumers are protected by the national control laboratories. Prior the pharmaceutical product is approved to the market; Several tests must be applied to ensure that these products meet the accepted standard of quality, efficacy and safety. However, time consuming method is usually stood as barrier to achieve fast results. This study concerns developing fast, simple, cheap, accurate and accessible analytical methods for the determination of selected anticoagulant drugs. Using reversed phase high performance liquid chromatography, stability study of tirofiban hydrochloride was studied. Moreover, tyrosine the synthetic starting material of tirofiban hydrochloride could be quantified from 1 æg mL-1. Tirofiban hydrochloride, rivaroxaban and apixaban ternary mixture could be determined accurately. Then, spectrofluorimetric methods were introduced for the determination of tirofiban hydrochloride and apixaban. Also, chemometric multivariate calibration techniques namely; classical least squares, principle component regression and partial least square regression were used for the simultaneous determination of tirofiban hydrochloride and tyrosine. Artificial neural networks were also applied to UV spectrophotometric data for the simultaneous determination of tirofiban hydrochloride and tyrosine | ||
| 530 | _aIssued also as CD | ||
| 653 | 4 | _aAnticoagulant drugs | |
| 653 | 4 | _aChemometry | |
| 653 | 4 | _aHigh performance liquid chromatography | |
| 700 | 0 |
_aEhab Farouk Hassan Elkady , _eSupervisor |
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| 700 | 0 |
_aNadia Fayek Youssef , _eSupervisor |
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| 700 | 0 |
_aRamzia Ismail Ibrahim Elbagary , _eSupervisor |
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| 905 |
_aNazla _eRevisor |
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| 905 |
_aSamia _eCataloger |
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| 942 |
_2ddc _cTH |
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| 999 |
_c66205 _d66205 |
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