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040 _aEG-GiCUC
_beng
_cEG-GiCUC
041 0 _aeng
049 _aDeposite
097 _aPh.D
099 _aCai01.10.10.Ph.D.2017.Ma.S
100 0 _aMarwa Mostafa Abdelrahman Ahmed
245 1 0 _aStudies of infectious coryza vaccine /
_cMarwa Mostafa Abdelrahman Ahmed ; Supervised Kamelia Mahmoud Osman , Osama Elsebaey Kamal
246 1 5 _aدراسات على لقاح مرض زكام الطيور المعدي
260 _aCairo :
_bMarwa Mostafa Abdelrahman Ahmed ,
_c2017
300 _a211 P. :
_bcharts , facsimiles , photographs ;
_c25cm
502 _aThesis (Ph.D.) - Cairo University - Faculty of Veterinary Medicine - Department of Microbiology
520 _aFour vaccines formula with different adjuvants (liquid paraffin oil (vaccine no. 1), MontanideTM ISA 71 (vaccine no. 2), MontanideTM ISA 201(vaccine no. 3) and MontanideTM Gel01 (vaccine no. 4)) and four vaccines formula by using Date palm (Phoenix dactylifera L) and Mentha piperita immunomodulators included in liquid paraffin oil adjuvant infectious coryza vaccine only in ratio of 1mg or 2mg of each immunomodulators, these 8 vaccines were used in vaccination of 8- 10 weeks old chickens and evaluated by using Microplate agglutination test (MAT), ELISA and challenge test. It was cleared that, vaccines no. 3, 4 and 2 yielded a maximum of significant (P < 0.05 ) higher and faster rate of antibody titer estimated by MAT and ELISA with a higher challenge protection percentage than vaccine no. 1. Evaluation of the humoral immune response of chicken vaccinated with liquid paraffin oil adjuvanated infectious coryza vaccine with 1 mg ( vaccine no. 5) and 2mg ( vaccine no. 6) of Date palm and also with 1mg ( vaccine no. 7 ) and 2mg ( vaccine no. 8) of Mentha piperta by using MAT, ELISA, cleared that antibody titer increase significantly (P < 0.05 ) at relative rates against the three antigens (W, Modesto, 0222) of Av. paragallinarum reaching maximum rates at the 10th to 12th week post immunization also the use of these immunomodulators give a higher protection percentage than vaccine no. 1. The data also cleared that the antibody titer was higher by using of 2mg of either Date palm or Mentha piperita included in the vaccine than using of 1mg. The results obtained in this study concluded that, the infectious coryza vaccine adjuvanted with either MontanideTM ISA71VG, MontanideTM ISA 201VG or MontanideTM Gel 01 adjuvant yielded immune response in chicken better than that adjuvanated with liquid paraffin oil. Also using an immunomodulators as Date palm and Mentha piperita included in liquid paraffin oil adjuvant infectious coryza vaccine can enhance immune response of chicken against infectious coryza disease
530 _aIssued also as CD
653 4 _aChicken against infectious coryza disease
653 4 _aInfectious coryza vaccine
653 4 _aMicrobiology
700 0 _aKamelia Mahmoud Osman ,
_eSupervisor
700 0 _aOsama Elsebaey Kamal ,
_eSupervisor
856 _uhttp://172.23.153.220/th.pdf
905 _aEnas
_eCataloger
905 _aNazla
_eRevisor
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_cTH
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