000			03201cam a2200349 a 4500
003			EG-GiCUC
005			20250223032007.0
008			180519s2017 ua dh f m 000 0 eng d
040			_aEG-GiCUC _beng _cEG-GiCUC
041	0		_aeng
049			_aDeposite
097			_aPh.D
099			_aCai01.11.32.Ph.D.2017.Ol.E
100	0		_aOla Mohamed Ali Hassan
245	1	0	_aEvaluation of serum and synovial fluid Interleukin-33 levels in patients with active rheumatoid arthritis : _bthe association with disease activity and clinical findings / _cOla Mohamed Ali Hassan ; Supervised Ola Mohamed Ragab , Noha Ahmed Azab , Mariam Halim Yacoub
246	1	5	_aتقييم مستوى انترلوكين-33 في الدم والسائل الزلالي في مرضى الروماتويد المفصلي النشط : _bالعلاقة بنشاط المرض والحالة الإكلينيكية
260			_aCairo : _bOla Mohamed Ali Hassan , _c2017
300			_a146 P. : _bcharts , facsimiles ; _c25cm
502			_aThesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Rheumatology and Rehabilitation
520			_aBackground:Cytokine-mediated immunity plays an important role in the pathogenesis of autoimmune diseases. Several studies have shown Interleukin-33 (IL-33) to be involved in the pathogenesis of various autoimmune diseases such as systemic lupus erythematosus , systemic sclerosis,ankylosing spondylitis, primary Sjogren{u2019}s syndrome and Behcet{u2019}s disease. Recent evidence suggests that IL-33, a newly found IL-1 family cytokine,exerted profound effects in human rheumatoid arthritis (RA) and experimental inflammatory arthritis. Aim of work:The aim of this study was to evaluate serum and synovial fluid IL33 levels in active RA patients and to investigate its possible association with disease activity, clinical and laboratory findings. Patients and methods: This study was conducted on 50 RA patients and 30 osteoarthritis (OA) patients serving as a control group. All patients were subjected to full history taking, clinical examination including Disease Activity Score 28 (DAS 28), laboratory investigations as well as plain radiographs of both hands and feet and chest x-ray. Bone erosion was evaluated using the modified Sharp Score (MSS). Matched serum and synovial fluid (SF) IL-33 levelswere measured by enzyme-linked immunosorbent assay. Results:Serum and synovial IL-33 levels were significantly higher in RA patients than in OA patients. Synovial IL33 level was significantly higher than the matched serum IL-33 level in RA patients. A statisticallyinsignificantassociation was found between serum and synovial IL-33 levels with ESR, CRP, tender joint count, swollen joint count, DAS28, disease duration, rheumatoid factor, anti-CCP antibody and MSS
530			_aIssued also as CD
653		4	_aInterleukin-33
653		4	_aMSS
653		4	_aRheumatoid Arthritis
700	0		_aMariam Halim Yacoub , _eSupervisor
700	0		_aNoha Ahmed Azab , _eSupervisor
700	0		_aOla Mohamed Ragab , _eSupervisor
856			_uhttp://172.23.153.220/th.pdf
905			_aNazla _eRevisor
905			_aShimaa _eCataloger
942			_2ddc _cTH
999			_c66240 _d66240