000			03128cam a2200349 a 4500
003			EG-GiCUC
005			20250223032008.0
008			180512s2016 ua dh f m 000 0 eng d
040			_aEG-GiCUC _beng _cEG-GiCUC
041	0		_aeng
049			_aDeposite
097			_aPh.D
099			_aCai01.24.03.Ph.D.2016.No.C
100	0		_aNoha Samy Hanafy
245	1	2	_aA comparative study between the effects of 308-NM excimer light and narrow-band ultraviolet b in the treatment of vitiligo / _cNoha Samy Hanafy ; Supervised Manal Mohamed Salah , Nevein Ahmed Samy , Dalia Gamal Aly
246	1	5	_aمقارنة ب{u٠٦أأ}ن تأث{u٠٦أأ}ر اشعه الاكس{u٠٦أأ}مر ( ٣٠٨ نانومتر) و الاشعه فوق البنفسج{u٠٦أأ}ة ض{u٠٦أأ}قة المدى (ب) في علاج مرض البهاق
260			_aCairo : _bNoha Samy Hanafy , _c2016
300			_a83 P. : _bcharts , facsimiles ; _c25cm
502			_aThesis (Ph.D.) - Cairo University - National Institute of Laser Enhanced Sciences - Department of Laser Applications in Medical and Biological
520			_aBackground: The 308-nm monochromatic Excimer light (MEL) may present some advantages as compared tonarrow band ultra-violet B(NBUVB) for the treatment of vitiligo. To the best of our knowledge, no studies compared the histopathological changes of vitiligo lesions before and after treatment by MEL and NBUVB. Aim: To compare the early effects of NBUVBphototherapy and 308-nm MEL in vitiligo patients histopathologically andimmunohistochemically. Patients and Methods: Thirty patients with non-segmental vitiligo were enrolled in this study. Vitiligo lesions were treated twice weekly for 6 weeks with 308-nm MEL, while NB-UVB phototherapy was used to treat lesions contra laterally. Skin biopsies were taken from lesional areas before and after 6 weeks of phototherapy by either modality for histopathological study withHaematoxylin & Eosin (H&E) and immunohistochemically using Human Melanoma Black-45 (HMB-45) stain. Results:Immunohistochemistry findings: All lesions before treatment had labeling index forHMB-45 stain (number of pigmented cells / non pigmented cells) of 0.0(0%). After treatment the LI for MEL was 4.2±2.6 while for NB UVB LI was 0.3±0.7. H&E findings: MEL showed higher statistical significance regarding increase of basal pigmented cells, and significant decrease in vacuolated keratinocytes and basal membrane thickness than NBUVB. Conclusions:Although NBUVB is a standard treatment option for vitiligo, MEL is recognized as an effective vitiligo treatment that induces more repigmentation than NB-UVB, and more rapidly, as this was confirmed by our study
530			_aIssued also as CD
653		4	_aMonochromatic Excimer Light (MEL)
653		4	_aNarrow Band Ultra-Violet B (NB UVB)
653		4	_aVitiligo
700	0		_aDalia Gamal Aly , _eSupervisor
700	0		_aManal Mohamed Salah , _eSupervisor
700	0		_aNevein Ahmed Samy , _eSupervisor
856			_uhttp://172.23.153.220/th.pdf
905			_aNazla _eRevisor
905			_aShimaa _eCataloger
942			_2ddc _cTH
999			_c66272 _d66272