| 000 | 03736cam a2200349 a 4500 | ||
|---|---|---|---|
| 003 | EG-GiCUC | ||
| 005 | 20250223032012.0 | ||
| 008 | 180602s2017 ua dh f m 000 0 eng d | ||
| 040 |
_aEG-GiCUC _beng _cEG-GiCUC |
||
| 041 | 0 | _aeng | |
| 049 | _aDeposite | ||
| 097 | _aPh.D | ||
| 099 | _aCai01.11.19.Ph.D.2017.Re.A | ||
| 100 | 0 | _aReham Mohamed Raafat Hamed | |
| 245 | 1 | 0 |
_aAssociation of serum IL-6 Level and its -174 G/C promoter polymorphism with clinical and laboratory characteristics of rheumatoid arthritis patients in Cairo University Hospitals / _cReham Mohamed Raafat Hamed ; Supervised Soliman Aref Mohamed , Reham Ali Dwedar , Yasmine Samy Elkholy |
| 246 | 1 | 5 | _aالخاص به في مرضي التهاب المفاصل الروماتويدى مع الخصائص السريرية والمختبرية للمرض في مستشفيات جامعة القاهرة في المصل والتعدد الجيني في المحفز 174جى/سى إرتباط مستوى 6آى إل |
| 260 |
_aCairo : _bReham Mohamed Raafat Hamed , _c2017 |
||
| 300 |
_a106 P. : _bcharts , facsimi ; _c25cm |
||
| 502 | _aThesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Microbiology and Immunology | ||
| 520 | _aBackground:Rheumatoid arthritis (RA) is a chronic progressive systemic inflammatory autoimmune disease of the joints, which can lead to long term joint damage, resulting in chronic pain, loss of function, and disability. Interleukin-6 (IL-6) encodes a cytokine protein, which causesinflammation, maintains immune homeostasis and plays an essentialrole in RA pathogenesis and IL-6 -174 G/C promoter polymorphism may play a role in susceptibility of RA. Aim of the work: To evaluate the clinical significance of serum levels of interleukin-6 (IL-6) and its-174 G/C promoter polymorphism in Rheumatoid arthritis (RA) patients and to compare with the controls. Patients and methods:This study enrolled 25 RA patients and 25 age and gender matched healthy controls. Demographic, clinical and serological data were prospectively evaluated. Disease activity score (DAS28) and radiological data were assessed. Serum IL-6 level was measured and promoter (-174G/C) genotyped. Results: Serum IL-6 levels were significantly higher in RA patients compared to the controls(pvalue = 0.001), especially those with CC promoter polymorphism. There was a significant correlation between IL-6 and duration of morning stiffness,disease activity,hemoglobin and ESR level. Fifteen patients had GG IL-6 (-174 G/G) gene promoter polymorphism, 8 were GC and 2 CC. ALL controls were GG. There wassignificant association between gene polymorphism and age at disease onset.The age at disease onset(p= 0.0172) was older in those with GG genotype (38.5± 10.25 years), 33.5 ±.71 years in those with CC genotype and was younger in with GC genotype (27.9± 7.9 years). None of the other studied parameters would predict the IL-6 promoter polymorphism. Conclusion:Serum IL-6 levels and -174 G/C promoter polymorphism were higher in RA patients than in healthy controls. The positive correlation of IL-6 with the DAS28 andduration of morning stiffness may confirm its{u2019} increased involvement in the pathogenesis of RA and may point to the need for considering of anti-IL-6 agents in their management plan | ||
| 530 | _aIssued also as CD | ||
| 653 | 4 | _a(-174 G/C) Promoter polymorphism | |
| 653 | 4 | _aIL-6 | |
| 653 | 4 | _aRheumatoid arthritis | |
| 700 | 0 |
_aReham Ali Dwedar , _eSupervisor |
|
| 700 | 0 |
_aSoliman Aref Mohamed , _eSupervisor |
|
| 700 | 0 |
_aYasmine Samy Elkholy , _eSupervisor |
|
| 856 | _uhttp://172.23.153.220/th.pdf | ||
| 905 |
_aNazla _eRevisor |
||
| 905 |
_aShimaa _eCataloger |
||
| 942 |
_2ddc _cTH |
||
| 999 |
_c66441 _d66441 |
||