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| 003 | EG-GiCUC | ||
| 005 | 20250223032013.0 | ||
| 008 | 180604s2017 ua dh f m 000 0 eng d | ||
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_aEG-GiCUC _beng _cEG-GiCUC |
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| 041 | 0 | _aeng | |
| 049 | _aDeposite | ||
| 097 | _aPh.D | ||
| 099 | _aCai01.21.09.Ph.D.2017.He.G | ||
| 100 | 0 | _aHeba Mohamed Abdelshafi | |
| 245 | 1 | 0 |
_aGallium arsenide laser efficacy on oral mucosal immunity in treating chemotherapy induced oral mucositis / _cHeba Mohamed Abdelshafi ; Supervised Awatif Mohamed Labib , Soheir Shehata Rezk Allah , Reem Jan Farid |
| 246 | 1 | 5 | _aتأثيرالجاليوم ارسنيد ليزرعلى مناعةالغشاء المخاطي للفم في علاج التهاب الأغشية المخاطية الفمية الناتج عن العلاج الكيميائي |
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_aCairo : _bHeba Mohamed Abdelshafi , _c2017 |
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_a191 P. : _bcharts , facsimiles ; _c25cm |
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| 502 | _aThesis (Ph.D.) - Cairo University - Faculty of Physical Therapy - Department of Basic Science | ||
| 520 | _aBackground: Oral mucositis is an inflammation of mucous membranes in the mouth which ranges from small patches and redness to severe ulceration and hemorrhage; it is a common complication of oncotherapy treatment affecting 40-80% of patients undergoing chemotherapy and almost all those undergoing radiotherapy of the head and neck. The purpose: of this study was to investigate the efficacy of gallium arsenide laser in chemotherapy induced oral Mucositis and level of tumor necrosis factor- alpha as well as interleukin-6 in cancer patients due to various malignancies. Subjects: Eighty cancer patients of both genders, smokers and non-smokers with age ranging from 40 to 65 years old were included, type of cancer was head and neck squamous cell carcinoma, lymphoma and breast cancer. They had oral mucositis of various degrees following chemotherapy treatment. They were randomly selected from the out and inpatient clinic of oncology department of Kasr Elaini hospital, and received chemotherapy in the form of Antimetabolites, Mitotic inhibitors, Anthracyclins, Alkylating agent, corticosteroids and immunotherapy from 4-8 cycles. Methods: World Health Organization assessment scale was used for mucositis assessment. Blood samples were taken from all patients for TNF-Ü and IL-6 assessment before and after treatment. All patients were treated with gallium arsenide laser (daily 6 days/week) from the start of oral mucositis. Results: There was a significant reduction in the grade of oral mucositis in almost all patients by 51.91 % with p-value = 0.001. Also there was a significant reduction in the grade of oral mucositis of non smoker patients (mean difference = 1.727) versus smoker patients (mean difference = 1.016) with p-value = 0.0001 for both status, younger patients (mean difference = 1.886) versus older patients (mean difference = 1.009) with p-value = 0.0001 for both ages, female patients (mean difference = 1.759) versus male patients (mean difference = 1.173) with p-value = 0.0001 for both genders. There was no significant changes in the mean value of TNF-Ü or IL-6 for the whole patients with p-value = 0.6965, p-value 0.0827 consequently. Conclusion: Gallium arsenide laser is effective in reducing chemotherapy induced oral mucositis in cancer patients due to various malignancies better results were obvious in younger non smoker female patients and mechanism of action does not seem to be completely linked to the changes of pro or anti-inflammatory cytokines | ||
| 530 | _aIssued also as CD | ||
| 653 | 4 | _aChemotherapy (CT) | |
| 653 | 4 | _aLow Power Laser Therapy (LPLT) | |
| 653 | 4 | _aOral Mucositis | |
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_aAwatif Mohamed Labib , _eSupervisor |
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| 700 | 0 |
_aReem Jan Farid , _eSupervisor |
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| 700 | 0 |
_aSoheir Shehata Rezkallah , _eSupervisor |
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| 856 | _uhttp://172.23.153.220/th.pdf | ||
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_aNazla _eRevisor |
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_aShimaa _eCataloger |
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