000 01815cam a2200325 a 4500
003 EG-GiCUC
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008 180725s2017 ua dh f m 000 0 eng d
040 _aEG-GiCUC
_beng
_cEG-GiCUC
041 0 _aeng
049 _aGift
097 _aM.Sc
099 _aCai01.34.M.Sc.2017.Ro.S
100 0 _aRowaida Adel Abdelhamid Hassan
245 1 0 _aSynthesis of Novel Heterocycle derivatives as potential phosphodiesterase inhibitors and anticancer /
_cRowaida Adel Abdelhamid Hassan ; Supervised Ashraf H. Abadi , Mohammed Abdelhalim
246 1 5 _aتشييد مشتقات جديدة من متعددة الحلقة وتقييمها كمثبطات لإنزيمات الفوسفودايستريزو كمضات للسرطان
260 _aCairo :
_bRowaida Adel Abdelhamid Hassan ,
_c2017
300 _a102 Leaves :
_bcharts , facsimiles ;
_c30cm
502 _aThesis (M.Sc.) - German University - Faculty of Postgraduate Studies and Scientific Research - Department of Pharmaceutical Chemistry
520 _aCyclicn nucleotide phosphodiesterase (PDEs) are promising targets for pharmacological ontervention. The presence of multiple PDE genes, diversity of the isoforms produced from each gene, selective tissue and cellular expression of the isoforms compartmentation within cells, and an array of conformations of PDE proteins are some of the properties that challenge the development of drugs that target these enzymes
653 4 _aAnticancer
653 4 _aCyclicn nucleotide phosphodiesterase (PDEs)
653 4 _aPhosphodiesterase inhibitors
700 0 _aAshraf H. Abadi ,
_eSupervisor
700 0 _aMohammed Abdelhalim ,
_eSupervisor
856 _uhttp://172.23.153.220/th.pdf
905 _aNazla
_eRevisor
905 _aShimaa
_eCataloger
942 _2ddc
_cTH
999 _c66868
_d66868