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008 | 180725s2017 ua dh f m 000 0 eng d | ||
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_aEG-GiCUC _beng _cEG-GiCUC |
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041 | 0 | _aeng | |
049 | _aGift | ||
097 | _aM.Sc | ||
099 | _aCai01.34.M.Sc.2017.Ro.S | ||
100 | 0 | _aRowaida Adel Abdelhamid Hassan | |
245 | 1 | 0 |
_aSynthesis of Novel Heterocycle derivatives as potential phosphodiesterase inhibitors and anticancer / _cRowaida Adel Abdelhamid Hassan ; Supervised Ashraf H. Abadi , Mohammed Abdelhalim |
246 | 1 | 5 | _aتشييد مشتقات جديدة من متعددة الحلقة وتقييمها كمثبطات لإنزيمات الفوسفودايستريزو كمضات للسرطان |
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_aCairo : _bRowaida Adel Abdelhamid Hassan , _c2017 |
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_a102 Leaves : _bcharts , facsimiles ; _c30cm |
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502 | _aThesis (M.Sc.) - German University - Faculty of Postgraduate Studies and Scientific Research - Department of Pharmaceutical Chemistry | ||
520 | _aCyclicn nucleotide phosphodiesterase (PDEs) are promising targets for pharmacological ontervention. The presence of multiple PDE genes, diversity of the isoforms produced from each gene, selective tissue and cellular expression of the isoforms compartmentation within cells, and an array of conformations of PDE proteins are some of the properties that challenge the development of drugs that target these enzymes | ||
653 | 4 | _aAnticancer | |
653 | 4 | _aCyclicn nucleotide phosphodiesterase (PDEs) | |
653 | 4 | _aPhosphodiesterase inhibitors | |
700 | 0 |
_aAshraf H. Abadi , _eSupervisor |
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700 | 0 |
_aMohammed Abdelhalim , _eSupervisor |
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856 | _uhttp://172.23.153.220/th.pdf | ||
905 |
_aNazla _eRevisor |
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_aShimaa _eCataloger |
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_2ddc _cTH |
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_c66868 _d66868 |