000 03019cam a2200349 a 4500
003 EG-GiCUC
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008 180806s2017 ua dh f m 000 0 eng d
040 _aEG-GiCUC
_beng
_cEG-GiCUC
041 0 _aeng
049 _aDeposite
097 _aM.Sc
099 _aCai01.11.28.M.Sc.2017.Sa.S
100 0 _aSalwa Fathy Mohamed
245 1 0 _aScreening for type 2 diabetes in high risk groups of egyptian children and adolescents /
_cSalwa Fathy Mohamed ; Supervised Mona Hassan Hafez , Mona Atteya Hana , Engy Adelmogahed
246 1 5 _aتحرى مرض السكرى من النوع الثانى فى المجموعات عالية الخطورة من الأطفال و المراهقين المصريين
260 _aCairo :
_bSalwa Fathy Mohamed ,
_c2017
300 _a140 P. :
_bcharts , facsimiles ;
_c25cm
502 _aThesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Pediatrics
520 _aBackground: T2DM can occur without any symptoms, and health problems associated with the disease are serious. With dramatic increases in the incidence and prevalence of T2DM among youth worldwide, screening tests allowing an early diagnosis are desirable. Aim of work: To estimate the prevalence of prediabetes and T2DM and their associated risk factors among obese and overweight high risk Egyptian children and adolescents using strip HbA1c as screening test compared to OGTT as the gold standard method. Patients and methods: A cross sectional study conducted on 339 children and adolescents of high risk groups for T2DM over a period of 10 months. Patients with hemoglobinopathies, known T1DM patients and children on steroid therapy were excluded from our study. The age of the study group ranged between 5-18 years. All those were subjected to full history taking, clinical evaluation, anthropometric measurements, and screened for prediabetes and T2DM using strip HbA1c and OGTT. Results: prevalence of prediabetes and T2DM using OGTT were 15% and 0.3% respectively, while strip HbA1c showed higher prevalence for prediabetes and T2DM (31%). Strip HbA1c showed 81.63% sensitivity and 76.84% specificity at cut off point {u2265}5.6 for prediabetes and diabetes. Moderate direct significant correlation between strip HbA1c and each of FBS and OGTT-Max was found (r=0.39 and 0.26 respectively). Significant association between age and prediabetes/T2DM was found using both OGTT and strip HbA1c (P value 0.03 and 0.001 respectively). Physical inactivity (P value 0.008), puberty, abdominal obesity, and presence of hirsutism were significantly associated with prediabetes and T2DM
530 _aIssued also as CD
653 4 _aHigh-risk
653 4 _aOGTT
653 4 _aPrediabetes
700 0 _aEngy Adelmogahed ,
_eSupervisor
700 0 _aMona Atteya Hana ,
_eSupervisor
700 0 _aMona Hassan Hafez ,
_eSupervisor
856 _uhttp://172.23.153.220/th.pdf
905 _aNazla
_eRevisor
905 _aSamia
_eCataloger
942 _2ddc
_cTH
999 _c66962
_d66962