000			02864cam a2200325 a 4500
003			EG-GiCUC
008			180806s2018 ua f m 000 0 eng d
040			_aEG-GiCUC _beng _cEG-GiCUC
041	0		_aeng
049			_aDeposite
097			_aPh.D
099			_aCai01.11.07.Ph.D.2018.Me.A
100	0		_aMenatallah Mohamed Saleh Elaguizy
245	1	0	_aAssociation of miR-18a, miR-21and miR-92a with colorectal carcinoma in a cohort of Egyptian patients / _cMenatallah Mohamed Saleh Elaguizy ; Supervised Ahmed Alsayed Altaweel , Marwa Mohamed Sheta , Ahmed Mostafa Ahmed
246	1	5	_aالعلاقة بين ميكرو آر إن ايه 18ا: 21 و 92 ا و سرطان القولون و المستقيم فى مجموعة من المرضى المصريين
260			_aCairo : _bMenatallah Mohamed Saleh Elaguizy , _c2018
300			_a134 P. ; _c25cm
502			_aThesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Clinical and Chemical Pathology
520			_aBackground: Colorectal cancer (CRC) is a major cause of cancer-related death worldwide. miRNAs have been demonstrated to play an important role in carcinogenesis either by oncogenic or tumor suppressor function. The aim of the present work is to study the serum levels of MiR-21, MiR-92a and MiR-18a to evaluate their potential use as biomarkers of CRC and to correlate their serum levels with the clinicopathological features to detect the prognostic potential of these miRNAs in patients with CRC. Subjects and methods: This study was conducted on 50 patients with CRC and 50 age and sex matched healthy volunteers used as a control group. Determination of the serum relative expression of each of three mature MiRNAs (MiR-21, MiR-92a and MiR-18a) was done after normalization to MiR-16 using the 2-xxCT method. Results: MiR-18a, MiR-21 and MiR-92a were found to be significantly up-regulated in serum of CRC patients (p<0.001, <0.001 and 0.003 respectively) compared to the healthy control group. ROC curve analyses demonstrated areas under the curve (AUC) of 0.906 [95% confidence interval (CI), 0.848{u2011}0.964], with 84% for both sensitivity and specificity for miR-18a, AUC=0.918 [95% CI, 0.866{u2011}0.971], with 84% sensitivity and 90% specificity for miR-21 and AUC=0.672 for miR-92a. Conclusions: MiR{u2011}18a and/or miR{u2011}21 could be helpful biomarkers while serum miR-92a has limited usefulness as a sole biomarker in CRC diagnosis. Combined serum miR-18a and miR-21 showed the highest sensitivity and specificity
530			_aIssued also as CD
653		4	_aCRC
653		4	_amiR-21
653		4	_amiRNAs
700	0		_aAhmed Alsayed Altaweel , _eSupervisor
700	0		_aAhmed Mostafa Ahmed , _eSupervisor
700	0		_aMarwa Mohamed Sheta , _eSupervisor
905			_aNazla _eRevisor
905			_aSamia _eCataloger
942			_2ddc _cTH
999			_c66966 _d66966