000			02833cam a2200349 a 4500
003			EG-GiCUC
005			20250223032028.0
008			180807s2017 ua d f m 000 0 eng d
040			_aEG-GiCUC _beng _cEG-GiCUC
041	0		_aeng
049			_aDeposite
097			_aM.Sc
099			_aCai01.11.29.M.Sc.2017.Ma.R
100	0		_aMahmoud Ahmed Abbas Khattab
245	1	0	_aRole of esomeprazole and magnesium sulfate in Pre-eclampsia induced experimentally in rats / _cMahmoud Ahmed Abbas Khattab ; Supervised Amani Nabil Shafik , Eman Hassan Abdelrahman , Rania Elsayed Hussein
246	1	5	_aدور ا{uئإئ٩}يسوميبرازول و الماغنيسيوم سلفات فى تسمم الحمل المحدث تجريبيا فى الجرذان
260			_aCairo : _bMahmoud Ahmed Abbas Khattab , _c2017
300			_a174 P. : _bcharts ; _c25cm
502			_aThesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Pharmacology
520			_aIntroduction: This study was an experimental study to investigate the role of Mg sulfate and esomeprazole on the treatment of the deleterious effects observed in experimentally induced preeclampsia in pregnant rats by L-NAME. Materials and methods: 40 adult pregnant females Sprague Dawley albino rats divided in to four groups. Group 1 controlled pregnant rats, Group 2 preeclampsia group induction with L-NAME (80 mg/kg/day) from gestational day 10 to end of pregnancy, Group 3 preeclampsia group treated with Mg sulfate (500mg/kg/day, orally) from gestational day 14 to the end of pregnancy and Group 4 preeclampsia group treated with Esomeprazole (3.5mg/kg/day, orally) starting from gestational day 14 to the end of pregnancy. Systolic blood pressure was recorded throughout pregnancy, EEG was recorded at gestational day 18. Blood samples from rat tail vein taken for estimation of serum Mg and soluble Endogolin levels at the start of pregnancy, gestational day 14 and at the end of pregnancy. Urine samples at the end of pregnancy taken for estimation of urine protien creatinine ratio. After delivery, maternal behaviour, reproductive outcome including total number of pups and fetal weights were assessed. Results: In comparison with the L-NAME group, Mg sulfate and esomeprazole treatment reduced the values of systolic blood pressure, proteinuria, EEG amplitude, prevented preterm labor and improved maternal behaviour after delivery and fetal outcomes
530			_aIssued also as CD
653		4	_aEndogolin
653		4	_aEsomeprazole
653		4	_aL-NAME
700	0		_aAmani Nabil Shafik , _eSupervisor
700	0		_aEman Hassan Abdelrahman , _eSupervisor
700	0		_aRania Elsayed Hussein , _eSupervisor
856			_uhttp://172.23.153.220/th.pdf
905			_aNazla _eRevisor
905			_aSamia _eCataloger
942			_2ddc _cTH
999			_c66973 _d66973