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| 003 | EG-GiCUC | ||
| 005 | 20250223032028.0 | ||
| 008 | 180807s2017 ua dh f m 000 0 eng d | ||
| 040 |
_aEG-GiCUC _beng _cEG-GiCUC |
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| 041 | 0 | _aeng | |
| 049 | _aDeposite | ||
| 097 | _aPh.D | ||
| 099 | _aCai01.11.07.Ph.D.2017.Sa.D | ||
| 100 | 0 | _aSally Hafez Mohamed Mohamed Hafez | |
| 245 | 1 | 0 |
_aDNA methylation levels of the insulin-like growth factor binding protein 1 gene in type 2 diabetes / _cSally Hafez Mohamed Mohamed Hafez ; Supervised Hazem Elsayed Abou Youssef , Mona Abdelkader Mohamed , Nehal Salah Hasan |
| 246 | 1 | 5 | _aفى مرضى داء السكرى من النوع الثانى IGFBP-1 مستوى مثيلة ال دى ان ايه لجين |
| 260 |
_aCairo : _bSally Hafez Mohamed Mohamed Hafez , _c2017 |
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| 300 |
_a180 P. : _bcharts , facsimiles ; _c25cm |
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| 502 | _aThesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Clinical and Chemical Pathology | ||
| 520 | _aType 2 diabetes is a complex trait with both environmental and hereditary factors contributing to the overall pathogenesis. One link between genes, environment, and disease is epigenetics influencing gene transcription and, consequently, organ function. Genome-wide studies have shown altered DNA methylation in tissues important for glucose homeostasis including pancreas, liver, skeletal muscle, and adipose tissue from subjects with type 2 diabetes compared with nondiabetic controls. Factors predisposing for type 2 diabetes including an adverse intrauterine environment, increasing age, overweight, physical inactivity, a family history of the disease, and an unhealthy diet have all shown to affect the DNA methylation pattern in target tissues for insulin resistance in humans. Epigenetics including DNA methylation may therefore improve our understanding of the type 2 diabetes pathogenesis, contribute to development of novel treatments, and be a useful tool to identify individuals at risk for developing the disease. This present study aimed to evaluate IGFBP1 gene methylation levels in peripheral blood of 100 subjects (50 T2DM patients versus 50 healthy controls) and to explore the role of IGFBP1 gene methylation in contribution to individual risk of T2D, using bisulfite pyrosequencing technique to identify IGFBP-1 gene methylation that may be involved in T2DM pathogenesis and prediction of the disease. Methylation of IGFBP-1 gene in T2DM group at each of the six CpG (P%) sites were statistically significant lower than the control group | ||
| 530 | _aIssued also as CD | ||
| 653 | 4 | _aDNA methylation | |
| 653 | 4 | _aIGFBP-1 | |
| 653 | 4 | _aType 2 diabetes | |
| 700 | 0 |
_aHazem Elsayed Abou Youssef , _eSupervisor |
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| 700 | 0 |
_aMona Abdelkader Mohamed , _eSupervisor |
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| 700 | 0 |
_aNehal Salah Hasan , _eSupervisor |
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| 856 | _uhttp://172.23.153.220/th.pdf | ||
| 905 |
_aNazla _eRevisor |
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| 905 |
_aSamia _eCataloger |
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_2ddc _cTH |
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_c66975 _d66975 |
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