| 000 | 03126cam a2200349 a 4500 | ||
|---|---|---|---|
| 003 | EG-GiCUC | ||
| 005 | 20250223032029.0 | ||
| 008 | 180809s2018 ua dh f m 000 0 eng | ||
| 040 |
_aEG-GiCUC _beng _cEG-GiCUC |
||
| 041 | 0 | _aeng | |
| 049 | _aDeposite | ||
| 097 | _aPh.D | ||
| 099 | _aCai01.08.09.Ph.D.2018.Ma.S | ||
| 100 | 0 | _aMarwa Mohamed Mahfouz | |
| 245 | 1 | 0 |
_aStudy of the possible neuroprotective effect of stem cells on an experimentally induced model for multiple sclerosis in experimental animals / _cMarwa Mohamed Mahfouz ; Supervised Sanaa A. Kenawy , Hanaa A. Mansour , Rania M. Abdelsalam |
| 246 | 1 | 5 | _aدرا{uئإآ٣}{uئإ٩٤} ا{uئإؤئ}{uئإ٩٨}{uئإ٨٤}{uئإ٩آ}{uئآئئ}{uئإءإ} ا{uئإؤئ}{uئإإإ}ا{uئإؤ٧}{uئإئ٠} ا{uئإؤئ}{uئإإ٤}{uئإء٤}{uئإ٩٨}{uئإإ٤}{uئإؤإ} {uئإؤئ}{uئإإ٠}{uئإء٨}{uئإئأ}{uئآئإ}{uئإ٨إ} ا{uئإؤئ}{uئإء٠}{uئإءأ}{uئإأآ}{uئآئئ}{uئإ٩٤} {uئإؤ٣}{uئإئ٠} {uئإإ٧}{uئإإ٤}{uئإإإ}ذج ا{uئإآ٣}{uئإ٩٨}{uئإء٤}{uئإءء}اث {uئإؤئ}{uئإإ٠}{uئإ٩٨}{uئإآأ}{uئإإ٠}{uئإ٩٠} ا{uئإؤئ}{uئإإ٤}{uئإ٩٨}{uئإأأ}{uئإءء}د {uئإؤ٣}{uئإئ٠} {uئإء٣}{uئآئئ}{uئإإإ}ا{uئإإ٧}{uئإ٨إ}ت ا{uئإؤئ}{uئإ٩٨}{uئإء٠}{uئإ٨إ}رب |
| 260 |
_aCairo : _bMarwa Mohamed Mahfouz , _c2018 |
||
| 300 |
_a176 P. : _bcharts , facsimiles ; _c25cm |
||
| 502 | _aThesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Pharmacology and Toxicology | ||
| 520 | _aMultiple sclerosis (MS) is a chronic autoimmune demyelinating neurodegenerative central nervous system disorder. The aim of the present study was to investigate the prophylactic effect exerted by the one-time intraperitoneal injection of mesenchymal stem cells (MSCs) 1{u00D7}106 and 14-day intraperitoneal injection of methylprednisolone (MP) 40 mg/kg in an experimental autoimmune encephalomyelitis (EAE) model. EAE was induced by intradermal injection of rat spinal cord homogenate with complete Freund{u2019}s adjuvant in Swiss mice. Results of MSCs and MP-treated mice showed a significantly milder disease and fewer clinical scores compared to control mice. They suppressed tumor necrosis factor-alpha and myeloperoxidase and increased interleukin 10, whereas thiobarbituric acid reactive substances and nitric oxide brain contents were reduced to comparable levels between treatment groups. Brain content of GSH was significantly higher in MSCs-treated mice than control mice. It is evident that MSCs have relevant prophylactic effect in an animal model of MS and might represent a valuable tool for stem cell based therapy in MS | ||
| 530 | _aIssued also as CD | ||
| 653 | 4 | _aEncephalomyelitis | |
| 653 | 4 | _aMethylprednisolone | |
| 653 | 4 | _aMice | |
| 700 | 0 |
_aHanaa A. Mansour , _eSupervisor |
|
| 700 | 0 |
_aRania M. Abdel Salam , _eSupervisor |
|
| 700 | 0 |
_aSanaa A. Kenawy , _eSupervisor |
|
| 856 | _uhttp://172.23.153.220/th.pdf | ||
| 905 |
_aNazla _eRevisor |
||
| 905 |
_aSamia _eCataloger |
||
| 942 |
_2ddc _cTH |
||
| 999 |
_c67003 _d67003 |
||