| 000 | 03325cam a2200349 a 4500 | ||
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| 003 | EG-GiCUC | ||
| 005 | 20250223032035.0 | ||
| 008 | 180829s2017 ua dh f m 000 0 eng d | ||
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_aEG-GiCUC _beng _cEG-GiCUC |
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| 041 | 0 | _aeng | |
| 049 | _aDeposite | ||
| 097 | _aM.Sc | ||
| 099 | _aCai01.11.30.M.Sc.2017.Mi.P | ||
| 100 | 0 | _aMina Joseph Aiad | |
| 245 | 1 | 0 |
_aPossible renal protective effect of thiamine & ACEI in modulating the course of nephrogenic complications in type II diabetic rats / _cMina Joseph Aiad ; Supervised Akef Abdelhalim Khowailed , Hanan Hassan Fouad , Mohamed Mansour Khalifa |
| 246 | 1 | 5 | _aالتأثير الوقائى المحتمل للثيامين ومثبط الإنزيم المحول للأنجيوتنسين فى تعديل المسار المرضى للمضاعفات الخاصة بالكلى فى الجرذان المصابة بمرض السكرى من النوع الثانى |
| 260 |
_aCairo : _bMina Joseph Aiad , _c2017 |
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| 300 |
_a119 P. : _bcharts , facsimiles ; _c25cm |
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| 502 | _aThesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Physiology | ||
| 520 | _aObjectives: Test the possible renoprotective effects of angiotensin converting enzyme inhibitor and thiamine in type 2 diabetic kidneys . Methods: A total of 50 adult albino rats were used in this study weighing 150-200 grams. The animals were housed in wire mesh cages at room temperature, with normal light/dark cycle. They were fed the commercial rat chow diet and had free access to water. These rats were divided into the following groups: : Group 1 : Control group, Group 2 : Type 2 diabetic rats, Group 3 : Type 2 diabetic nephropathy rats, Group 4 : Lisinopril-treated type 2 diabetic nephropathy rats, Group 5 : Thiamine mononitrate-treated type 2 diabetic nephropathy rats. Blood samples were collected for measurement of fasting blood glucose, fasting blood insulin, blood urea and blood albumin creatinine ratio . Homeostasis model assessment of insulin resistance was calculated. Urine samples were collected for measurement of urinary albumin excretion. Systolic blood pressure and diastolic blood pressure were also measured . Nuclear factor kappa B gene expression was estimated . Results: Treatment with angiotensin converting enzyme inhibitor reduced fasting blood glucose, fasting blood insulin, blood urea, urinary albumin excretion, nuclear factor kappa B gene expression, systolic blood pressure and diastolic blood pressure. Treatment with thiamine mononitrate reduced fasting blood glucose, blood urea, urinary albumin excretion and systolic blood pressure. Conclusion: The use of angiotensin converting enzyme inhibitor and thiamine in the treatment of kidney disease with type 2 diabetes significantly offered renal protection and improved the diabetic condition and may postpone the onset of renal injury in a type 2 diabetic rats | ||
| 530 | _aIssued also as CD | ||
| 653 | 4 | _aDiabetes | |
| 653 | 4 | _aNuclear factor kappa B | |
| 653 | 4 | _aThiamine | |
| 700 | 0 |
_aAkef Abdelhalim Khowailed , _eSupervisor |
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| 700 | 0 |
_aHanan Hassan Fouad , _eSupervisor |
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| 700 | 0 |
_aMohamed Mansour Khalifa , _eSupervisor |
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| 856 | _uhttp://172.23.153.220/th.pdf | ||
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_aNazla _eRevisor |
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_aShimaa _eCataloger |
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_2ddc _cTH |
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_c67192 _d67192 |
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