000 02450cam a2200349 a 4500
003 EG-GiCUC
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008 180910s2017 ua dh f m 000 0 eng d
040 _aEG-GiCUC
_beng
_cEG-GiCUC
041 0 _aeng
049 _aDeposite
097 _aPh.D
099 _aCai01.11.03.Ph.D.2017.Ay.E
100 0 _aAyman Mohammed Hany
245 1 0 _aExpression of Micro RNAs 206 and 133b and serum IL-17 levels in preeclamptic females /
_cAyman Mohammed Hany ; Supervised Yasser Hussein Nassar, Mostafa Mohammed Mostafa , Salah Aly Sanad
246 1 5 _aفى النساء اللآى يعانين من تسمم الحملIL-17ومستوى مصل b133, 306التعبير الجين لميكرو ار ان ايه
260 _aCairo :
_bAyman Mohammed Hany ,
_c2017
300 _a156 P. :
_bcharts , facsimiles ;
_c25cm
502 _aThesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Medical Biochemistry
520 _aThe human placenta is a rapidly evolving organ that harbors a rich and diverse transcriptome. It is estimated that 66% of all human proteins are expressed in the placenta (Uhlen et al., 2016). Not surprisingly, the human placenta also expresses numerous types of miRNA species, with a fraction of these species being specific to trophoblasts (Luo et al., 2009).MicroRNAs (miRNAs) are small noncoding RNAs that act at a posttranscriptional level to degrade target genes recognized by complementary base pairing in the 3{u2019}untranslated region of the mRNA.Through inhibition of protein translation or promotion of mRNA degradation, miRNAs have roles in physiological and pathological processes such as cell differentiation, proliferation/growth, apoptosis, angiogenesis, inflammation, redox signaling and other endothelial cell functions (Zhang 2008). Since these processes are disrupted in preeclampsia,miRNAs can potentially play significant roles in preeclampsia pathogenesis. miRNAs may provide a novel strategy for better understanding of preeclampsia and its diagnosis
530 _aIssued also as CD
653 4 _a133b
653 4 _aMicro RNAs 206
653 4 _aSerum IL-17
700 0 _aMostafa Mohammed Mostafa ,
_eSupervisor
700 0 _aSalah Aly Sanad ,
_eSupervisor
700 0 _aYasser Hussein Nassar ,
_eSupervisor
856 _uhttp://172.23.153.220/th.pdf
905 _aNazla
_eRevisor
905 _aShimaa
_eCataloger
942 _2ddc
_cTH
999 _c67413
_d67413