| 000 | 02621cam a2200349 a 4500 | ||
|---|---|---|---|
| 003 | EG-GiCUC | ||
| 005 | 20250223032042.0 | ||
| 008 | 180912s2018 ua dh f m 000 0 eng d | ||
| 040 |
_aEG-GiCUC _beng _cEG-GiCUC |
||
| 041 | 0 | _aeng | |
| 049 | _aDeposite | ||
| 097 | _aM.Sc | ||
| 099 | _aCai01.11.30.M.Sc.2018.En.E | ||
| 100 | 0 | _aEnas Samy Ibraheem Ali Elsisi | |
| 245 | 1 | 0 |
_aEffect of vitamin D on cognitive dysfunction in diabetic ovariectomized rats / _cEnas Samy Ibraheem Ali Elsisi ; Supervised Nahed Salah Eldin , Laila Ahmed Rashed , Nancy Fouad Samir |
| 246 | 1 | 5 | _aتأثير فيتامين د علي اختلال الوظائف المعرفية المصاحبة لداء السكري في اناث الفئران بعد استئصال المبايض |
| 260 |
_aCairo : _bEnas Samy Ibraheem Ali Elsisi , _c2018 |
||
| 300 |
_a165 P. : _bcharts , facsimiles ; _c25cm |
||
| 502 | _aThesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Physiology | ||
| 520 | _aBackground:Both Diabetes mellitus and menopause cause imbalance of neurotransmitter systems in different brain areas leading to deterioration of cognition. Vitamin D is a neurohormone involved in the regulation of cognitive functions through affecting neurotransmitter systems in the brain. Objective: The purpose of the present study is toinvestigate the combined effect of diabetes and ovariectomy on cognition andon the gene expression of cholinergic, dopaminergic and vitamin D receptor neurotransmitter systems in the cortex and hippocampus, and toevaluate the effect of vitamin D treatment on cognitive functions, and its possible impact on these neurotransmitter systems. Methods: Fifty female albino rats were divided into 5 groups (10 rats/group); Control,diabetic(Streptozotocin 60 mg/kg, Intraperitoneal), ovariectomy,diabetic ovariectomized, and diabetic ovariectomized rats receiving oral vitamin D (12 microgram/kg/d for 5 weeks). At the end of the study blood glucose and estradiol levelswere measured and cognitive functions were assessed by open field and T-maze test. After decapitation, cerebral cortex and hippocampus were preserved for assay of cholinergic, dopaminergic and vitamin D receptors gene expression | ||
| 530 | _aIssued also as CD | ||
| 653 | 4 | _aCognition | |
| 653 | 4 | _aDiabetes | |
| 653 | 4 | _aVitamin D | |
| 700 | 0 |
_aLaila Ahmed Rashed , _eSupervisor |
|
| 700 | 0 |
_aNahed Salah Eldin , _eSupervisor |
|
| 700 | 0 |
_aNancy Fouad Samir , _eSupervisor |
|
| 856 | _uhttp://172.23.153.220/th.pdf | ||
| 905 |
_aNazla _eRevisor |
||
| 905 |
_aShimaa _eCataloger |
||
| 942 |
_2ddc _cTH |
||
| 999 |
_c67421 _d67421 |
||