000			03376cam a2200349 a 4500
003			EG-GiCUC
005			20250223032042.0
008			180912s2017 ua d f m 000 0 eng d
040			_aEG-GiCUC _beng _cEG-GiCUC
041	0		_aeng
049			_aDeposite
097			_aM.Sc
099			_aCai01.12.21.M.Sc.2017.Sh.I
100	0		_aShrouk Khalaf Elsayed Ahmed Ali
245	1	0	_aInterleukin-10 gene polymorphism in Egyptian breast cancer patients / _cShrouk Khalaf Elsayed Ahmed Ali ; Supervised Mona Mostafa Mohamed , Salwa Farouk Sabet , Mohamed Elsayed Elshinawi
246	1	5	_aالتنميط الجيني للانترلوكين 10 في مرضى سرطان الثدي المصريين
260			_aCairo : _bShrouk Khalaf Elsayed Ahmed Ali , _c2017
300			_a108 P. : _bcharts ; _c25cm
502			_aThesis (M.Sc.) - Cairo University - Faculty of Science - Department of Zoology
520			_aBreast cancer isthe main cause of death in women worldwide. Indeed, genetic variation plays a vital role in carcinogenesis. Inflammatory breast cancer (IBC) is an aggressive and fatal form of breast cancer that is more prominent among young women and is characterized by a high number of axillary lymph node metastases at the time of presentation, poor prognosis and low survival rate(Mohamed et al. 2008; Nouh et al. 2011; Victor et al. 2011; Mohamed 2012; Mohamed et al. 2014)(Mohamed et al. 2008; Nouh et al. 2011; Victor et al. 2011; Mohamed 2012; Mohamed et al. 2014)(Mohamed et al. 2008; Nouh et al. 2011; Victor et al. 2011; Mohamed 2012; Mohamed et al. 2014)(Mohamed et al. 2008; Nouh et al. 2011; Victor et al. 2011; Mohamed 2012; Mohamed et al. 2014)(Mohamed et al. 2008; Nouh et al. 2011; Victor et al. 2011; Mohamed 2012; Mohamed et al. 2014). Interleukin-10 is involved in carcinogenesis by supporting tumor escape from the immune response. The aim of this study was to assess the single nucleotide polymorphisms, -1082A/G, -819T/C and -592A/C, in interleukin-10 gene promoter in inflammatory breast cancer compared to non-inflammatory breast cancer and association of these polymorphisms with interleukin-10 gene expression. As we targeted the most commonly three studied IL-10 promoter SNPs; rs1800896 ({u2212}1082A/G), rs1800871 ({u2212}819T/ C) and rs1800872 ({u2212}592A/C), GCC haplotype was found in association with over-increase in the risk of IBC. Also we found no association of IL-10 gene promoter polymorphisms in breast cancer progression (Stage, Grade, lymph node metastasis and distant metastasis). Moreover, we found increased expression of IL-10 gene in non-IBC and IBC than healthy control samples but a higher significant expression of IL-10 mRNA in IBC carcinoma tissues compared to non-IBC. GCC haplotype was the most correlated with increased expression of IL-10 than other estimated haplotype, and a markedly significant increase in IL-10 expression of GCC haplotype in IBC than non-IBC carcinoma tissue
530			_aIssued also as CD
653		4	_aHaplotype
653		4	_aInflammatory breast cancer
653		4	_aInterleukin-10
700	0		_aMohamed Elsayed Elshinawi , _eSupervisor
700	0		_aMona Mostafa Mohamed , _eSupervisor
700	0		_aSalwa Farouk Sabet , _eSupervisor
856			_uhttp://172.23.153.220/th.pdf
905			_aNazla _eRevisor
905			_aShimaa _eCataloger
942			_2ddc _cTH
999			_c67431 _d67431