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040 _aEG-GiCUC
_beng
_cEG-GiCUC
041 0 _aeng
049 _aDeposite
097 _aM.Sc
099 _aCai01.12.25.M.Sc.2018.Sa.A
100 0 _aSamar Samir Abdelrahman Abdelmajed Elkhateeb
245 1 0 _aAssociation analysis of FTO gene polymorphism and obesity risk among Egyptian children and adolescents /
_cSamar Samir Abdelrahman Abdelmajed Elkhateeb ; Supervised Mohamed Mohamed Mohamed Yousef , Somaia Mohamed Ismail
246 1 5 _aو خطر الإصابة بمرض السمنة بين الأطفال والمراهقين المصريين FTO تحليل الارتباط ما بين التعدد الشكلى فى جين
260 _aCairo :
_bSamar Samir Abdelrahman Abdelmajed Elkhateeb ,
_c2018
300 _a93 P. :
_bcharts , facsimiles ;
_c25cm
502 _aThesis (M.Sc.) - Cairo University - Faculty of Science - Department of Biotechnology
520 _aBackground: Obesity is a common disorder that has a significant impact on human health as it may lead to many serious diseases and sometimes morbidity. Previous genome-wide association studies (GWAS) confirmed that there is a relationship between some variants in the first intron of the fat mass and obesity-associated (FTO) gene and obesity in adults and children in different ethnic groups. Objective: In our study, the association of the FTO rs9939609 and rs17817449 variants with obesity was investigated in Egyptian children and adolescents. Subjects and methods: We examined rs9939609 and rs17817449 polymorphisms in 100 control and 100 obese cases, we used the restriction fragment length polymorphism (RFLP) technique to genotype the samples. Results: The current study showed that there were no significant differences between the cases and controls in both variants of rs17817449 and rs9939609. However, there were significant correlations between rs17817449 and cholesterol and between rs9939609 and LDL
530 _aIssued also as CD
653 4 _aFat mass and obesity associated gene (FTO)
653 4 _aObesity
653 4 _aVariants
700 0 _aMohamed Mohamed Mohamed Yousef ,
_eSupervisor
700 0 _aSomaia Mohamed Ismail ,
_eSupervisor
856 _uhttp://172.23.153.220/th.pdf
905 _aNazla
_eRevisor
905 _aShimaa
_eCataloger
942 _2ddc
_cTH
999 _c67483
_d67483