000			02808cam a2200325 a 4500
003			EG-GiCUC
008			181020s2017 ua d f m 000 0 eng d
040			_aEG-GiCUC _beng _cEG-GiCUC
041	0		_aeng
049			_aDeposite
097			_aPh.D
099			_aCai01.11.07.Ph.D.2017.Im.R
100	0		_aIman Sami Aboubakr Elbayoumi
245	1	0	_aRole of natural killer and activating receptors in rheumatoid arthritis / _cIman Sami AbouBakr Elbayoumi ; Supervised Shereen Mahmoud Shawky , Mariam Onsy Farag , Hala Ahmed Raafat
246	1	5	_aدور المستقبلات الناشطة للخلايا الطبيعية القاتلة فى مرض روماتويد المفاصل
260			_aCairo : _bIman Sami Aboubakr Elbayoumi , _c2017
300			_a211, 26 P. : _bcharts ; _c25cm
502			_aThesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Clinical and Chemical Pathology
520			_aIntroduction: Rheumatoid arthritis (RA) is a common chronic autoimmune disease (AID). The impaired activity of the effector lymphocytes: NK cells, T cells and NKT cells, has been detected in RA. Dysregulation of Natural Killer Receptors (NKRs) in patients with RA has been shown. In Egypt, the prevalence rate of HCV (genotype 4) reaches 20%. Because of the high prevalence of the two diseases, HCV-infected patients having arthritis, and classical RA with concomitant HCV, pose a diagnostic problem for rheumatologists. Objectives: In the present work we aimed to study the characterization: The count and the NKRs (CD16 and CD244) expression on the three types of effector lymphocytes, in RA patients and in RA patients with concomitant HCV to investigate their role in the pathogenesis of RA and to detect the difference between their character in RA patients and RA with HCV. Patients and methods: The count of NK, T and NKT cells, the expression of CD16 and CD244 on the 3 effector lymphocytes, were evaluated in 20 RA patients, 21 RA patients with HCV and 17 healthy control with flow cytometry. Cytokines influencing NK cell as TNF-Ü and IL-6 were measured by IRMA and by ELISA respectively. Results: Our main finding was the significantly reduced MFI of CD16 and CD244 on NK, T and NKT cells, in the RA patients with HCV and RA without HCV, compared to the control and a significant increase of percentage and absolute NKT cell count, in the RA patients with HCV and RA without HCV compared to the healthy control
530			_aIssued also as CD
653		4	_aCD16
653		4	_aHepatitis C virus
653		4	_aRheumatoid arthritis
700	0		_aHala Ahmed Raafat , _eSupervisor
700	0		_aMariam Onsy Farag , _eSupervisor
700	0		_aShereen Mahmoud Shawky , _eSupervisor
905			_aNazla _eRevisor
905			_aSamia _eCataloger
942			_2ddc _cTH
999			_c68102 _d68102