000			03245cam a2200349 a 4500
003			EG-GiCUC
005			20250223032106.0
008			181027s2018 ua dh f m 000 0 eng d
040			_aEG-GiCUC _beng _cEG-GiCUC
041	0		_aeng
049			_aDeposite
097			_aM.Sc
099			_aCai01.11.29.M.Sc.2018.Di.P
100	0		_aDina Anwar Ibrahim
245	1	4	_aThe potential effect of doxycycline versus pregabalin on neuropathic pain in streptozotocin induced diabetes in rats / _cDina Anwar Ibrahim ; Supervised Eman Abdelmonem Abdelrasheed , Olfat Gamil Shaker , Magdy Ishak Attallah
246	1	5	_aالتاثير المحتمل لدواء الدوكسيسيكلين مقارنة بالبريجابالين على الالم الاختلالى العصبى الناتج من مرض السكر المحدث بالستربتوزوتوسين فى الجرذان
260			_aCairo : _bDina Anwar Ibrahim , _c2018
300			_a156 P. : _bcharts , facsimiles ; _c25cm
502			_aThesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Pharmacology
520			_aBackground and aim: Diabetic neuropathy (DN) is a major complication of diabetes frequently accompanied with pain sensation. Pathogenesis of painful diabetic neuropathy is multifactorial. Many factors including metabolic, vascular and immunological components are involved in the pathogenesis. Doxycycline, a second generation tetracycline, is well known to have anti-inflammatory effect beyond its antimicrobial activity. Objectives: The present study was designed to investigate the potential role of Doxycycline in treatment of painful diabetic neuropathy in comparison with pregabalin materials and methods: Male wistar strain rats weighing (150-200g) were used. Diabetic neuropathy was induced in rat by I.P. injection of single dose of STZ 50mg/kg. Two doses of Doxycycline 50 and 100 mg/kg were examined. Pregabalin was used as a standard drug for comparison. Tests for mechanical and thermal allodynia and hyperalgesia were used to assess the antinociceptive effect of the tested drugs. The serum level of glucose and HBA1C were measured and the level of IL-1Ý and TNF-Ü in spinal cord homogenate were measured. Moreever, histopathological examination of sciatic nerve was done. Results: The results of the present study showed that doxycycline administration in the two specified doses showed significant improvement of measurement of all behavioral tests including hot plate, analgesy-meter tests and acetone test which was comparable with that occurred with administration of Pregabalin. Both doxycycline tested doses and pregabalin administrated to hyperglycemic rats produced significant reduction in levels of IL1 beta and TNF alpha in spinal cord homogenate and significant reduction of blood glucose level in diabetic rats
530			_aIssued also as CD
653		4	_aDoxycycline
653		4	_aNeuropathic pain
653		4	_aPregabalin
700	0		_aEman Abdelmonem Abdelrasheed , _eSupervisor
700	0		_aMagdy Ishak Attallah , _eSupervisor
700	0		_aOlfat Gamil Shaker , _eSupervisor
856			_uhttp://172.23.153.220/th.pdf
905			_aNazla _eRevisor
905			_aSamia _eCataloger
942			_2ddc _cTH
999			_c68185 _d68185