000			03191cam a2200325 a 4500
003			EG-GiCUC
008			181124s2017 ua dh f m 000 0 eng d
040			_aEG-GiCUC _beng _cEG-GiCUC
041	0		_aeng
049			_aDeposite
097			_aM.Sc
099			_aCai01.11.04.M.Sc.2017.Ah.R
100	0		_aAhmed Amin Elmogy
245	1	0	_aRenal involvement in infective endocarditis : _bCauses and its impact on in-hospital outcome / _cAhmed Amin Elmogy ; Supervised Yasser A. Sharaf , Marwa S. Meshaal , Ghada M. Reda
246	1	5	_aارتفاع وظائف الكلي بمرضي شغاف القلب : _bاسبابه ومدي تاثيره خلال مدة الاقامة بالمستشفي
260			_aCairo : _bAhmed Amin Elmogy , _c2017
300			_a96 P. : _bcharts , facsimiles ; _c25cm
502			_aThesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Cardiology
520			_aBackground: Infective endocarditis (IE) is considered to be a global burden both socially and economically particularly in developing countries as Egypt. Renal involvement related to this disease is common and adds significantly to its rising morbidity and mortality.Purpose: In this prospective longitudinal observational study, 58 patients, diagnosed as definite or possible IE, were evaluated for the incidence and predictors of renal involvement and its impact on in-hospital outcome.Methods: Fifty eight patients were admitted to the cardiology department.They were evaluated clinically, laboratory and with various imaging modalities. Assessing renal involvement has included serum urea, creatinine level, estimated glomerular filtration rate by Cockcroft-Gault equation, urine analysis for gross or microscopic hematuria and proteinuria. Development of significant renal impairment was defined as rise of serum creatinine to 2 mg/dl or more on admission or at any point during hospital stay after exclusion chronic kidney disease patients.Results: The prevalence of renal involvement in patients with IE was 65.5%.The incidence of significant renal impairment (defined previously) was found to be 41.4%. Heart failure and shock requiring vasopressor support were highly significant predictor for significant renal impairment. Inaddition markers of sepsis, either clinical as tachycardia and hyperthermia or laboratory as high C-reactive protein level, leukocytosis, thrombocytopenia and hypoalbuminemia, have been proven to be predictors of significant renal impairment.The most common complications that have occurred are; heart failure (51.7%), systemic embolization (51.7%), pulmonary embolism (31%) and septic shock (15.5%). Overall mortality rate during index hospitalization was 34.5 %. Significant renal involvement was found to be strong predictor for in-hospital mortality (p <0.001)
530			_aIssued also as CD
653		4	_aHigh C-reactive protein level
653		4	_aInfective endocarditis
653		4	_aRenal involvement
700	0		_aGhada M. Reda , _eSupervisor
700	0		_aMarwa S. Meshaal , _eSupervisor
700	0		_aYasser A. Sharaf , _eSupervisor
905			_aNazla _eRevisor
905			_aShimaa _eCataloger
942			_2ddc _cTH
999			_c68679 _d68679