000			03433cam a2200349 a 4500
003			EG-GiCUC
005			20250223032135.0
008			181219s2018 ua dh f m 000 0 eng d
040			_aEG-GiCUC _beng _cEG-GiCUC
041	0		_aeng
049			_aDeposite
097			_aPh.D
099			_aCai01.10.05.Ph.D.2018.Ma.P
100	0		_aMarwa Ali Abdelmagid Hassan
245	1	0	_aPathological study on green tea effect on experimentally infected chickens with highly pathogenic strain of avian influenza virus (H5N1)/ _cMarwa Ali Abdelmagid Hassan ; Supervised Hala Mohamed Farouk Elminiawy , Gehan Gamil Ahmed , Sherein Saeid Abdelgayeed
246	1	5	_aH5N1 دراسة باثولوجية على تأثير الشاى الأخضر على الدجاج المعدى تجريبيا بفيروس انفلوانزا الطيور شديد الضراوة
260			_aCairo : _bMarwa Ali Abdelmagid Hassan , _c2018
300			_a137 P. : _bcharts , facsilmes ; _c25cm
502			_aThesis (Ph.D.) - Cairo University - Faculty of Veterinary Medicine - Department of Cilinical Pathology
520			_aAvian influenza virus; one of the most important zoonotic diseases that{u2019}s not only pose athreat to the poultry industry but also high risk to the humans and environment. Although; many efforts are made to control it to reduce its risk globally mainly through stamping out or vaccination particularly in Egypt, it{u2019}s still spreading and become endemic in Egypt since 2008. Therefore, recent attention has been directed to alternative medicine because of its many health benefits and antiviral effects. In this study we evaluated the antiviral efficacy of green tea extract on highly pathogenic avian influenza virus (H5N1).Different concentrations of methanolicgreen tea extract were inoculated into vero cell line and to ECE to study its cytotoxicity and antiviral effect in-vitro.120 one day old SPF chicks were divided into 8 groups (15 birds/group); group (A) negative control, group (B) GTE control, group (C) positive control, group (D) supplied with GTE from beginning of the experiment, group (E) supplied with GTE 4hs before challenge, group (F) supplied with GTE 24hs post challenge,group (G) vaccinated with inactivated vaccine (Re-1) on the 7th day old and group (H) supplied by GTE from beginning of the experiment and vaccinated. GTE used 5gm/literin drinking water. The challenge was applied on the 28th day old using HPAI (H5N1)106 EID50/100æl/bird through I/N rout.Our results revealed desirable effect in-vitroby marked decreasing in viral cytopathic effect on treated vero cells as well as decreasing the hemagglutinating titer in tested allantoic fluid of treated ECE group. Obvious antiviral efficacy of GTE was detected in-vivo including decreases in viral shedding of treated groups; particularly in vaccinated treated one, clear histopathologicalimprovement oflung of treated groups which confirmed by variable detection of viral antigen by immunohistochemistry and morphometric analysis
530			_aIssued also as CD
653		4	_aAntiviral
653		4	_aAvian influenza
653		4	_aH5N1
700	0		_aGehan Gamil Ahmed , _eSupervisor
700	0		_aHala Mohamed Farouk Elminiawy , _eSupervisor
700	0		_aSherein Saeid Abdelgayeed , _eSupervisor
856			_uhttp://172.23.153.220/th.pdf
905			_aNazla _eRevisor
905			_aShimaa _eCataloger
942			_2ddc _cTH
999			_c69161 _d69161