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| 005 | 20250223032138.0 | ||
| 008 | 181224s2018 ua dh f m 000 0 eng d | ||
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_aEG-GiCUC _beng _cEG-GiCUC |
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| 041 | 0 | _aeng | |
| 049 | _aDeposite | ||
| 097 | _aPh.D | ||
| 099 | _aCai01.19.03.Ph.D.2018.Sa.E | ||
| 100 | 0 | _aSalwa Aly Elsaid Senoun | |
| 245 | 1 | 0 |
_aExpression of micro-RNA 128 and Let-7b in pediatric ALL / _cSalwa Aly Elsaid Senoun ; Supervised Nahed Abdelwahab Mohamed , Emad Nabil Ebed , Maha Abdelhamid Eltaweel |
| 246 | 1 | 5 | _aبي7في سرطان الدم الليمفي الحاد عند الأطفال- Let-128- RNAظهور ميكرو |
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_aCairo : _bSalwa Aly Elsaid Senoun , _c2018 |
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_a150 P. : _bcharts , facsimiles ; _c25cm |
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| 502 | _aThesis (Ph.D.) - Cairo University - National Cancer Institute - Department of Clinical Pathology | ||
| 520 | _aBackground: Recently, growing evidence has implicated specific miRNAs in the pathogenesis of leukemia and circulating miRNAs could serve as noninvasive biomarkers for detection of leukemia. In tumor cells, miR-128 expression is dysregulated through a variety of genetic and epigenetic events. Deregulation of Let-7 in various cancers suggest that Let-7 may have different functions in different diseases or in different cell contexts. Aim of the work: to evaluate the expression of both miRNAs, miR-128 and Let-7b, in a newly diagnosed bone marrow samples from children with Acute Lymphoblastic Leukemia (ALL) and to correlate their expression levels with clinical and Laboratory data. Material and methods: Detection of micro-RNA 128 and Let-7b using RTPCR in 70 newly diagnosed ALL pediatric patients and 7 age and sex comparable healthy control. Results: we found that miR128 was significantly upregulated in pediatric ALL bone marrow (BM) samples compared to control BM samples (P<0.001).however, no statistical significant difference in Let -7b expression between pediatric ALL group compared to control group (P=0.126). Conclusion: miR-128 was found to be expressed at a significantly higher level in ALL than in normal subjects, which may help to provide new insights into the diagnosis of childhood ALL and that the role of Let -7b has to be verified by further large scale sample and further studies | ||
| 530 | _aIssued also as CD | ||
| 653 | 4 | _aLet-7b | |
| 653 | 4 | _aMicro-RNA 128 | |
| 653 | 4 | _aPediatric ALL | |
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_aEmad Nabil Ebed , _eSupervisor |
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| 700 | 0 |
_aMaha Abdelhamid Eltaweel , _eSupervisor |
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| 700 | 0 |
_aNahed Abdelwahab Mohamed , _eSupervisor |
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| 856 | _uhttp://172.23.153.220/th.pdf | ||
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_aNazla _eRevisor |
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_aShimaa _eCataloger |
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