000			03222cam a2200337 a 4500
003			EG-GiCUC
005			20250223032144.0
008			190103s2018 ua do f m 000 0 eng d
040			_aEG-GiCUC _beng _cEG-GiCUC
041	0		_aeng
049			_aDeposite
097			_aM.Sc
099			_aCai01.09.12.M.Sc.2018.Li.C
100	0		_aLina Ahmed Mohamed Helmy
245	1	0	_aComparative analysis of the effect of stevia and fructose versus aspartame on the histological structure and the expression of Anti-p53 and Anti-NF-mB antibodies in the submandibular salivary glands of albino rats : _bAn animal study / _cLina Ahmed Mohamed Helmy ; Supervised Samia Mostafa Kamal , Marwa Magdy Saad
246	1	5	_a مقارنة بين تأثير الستيفا و الفركتوز ضد الأسبارتام على التكوين الهيستولوجى و تعبير الأجسام المضادة لمضادات (إن إف-كى بى و بى53)فى الغدد اللعابية تحت الفكية فى الجرذان البيضاء : _bدراسة على الحيوان
260			_aCairo : _bLina Ahmed Mohamed Helmy , _c2018
300			_a157 P. : _bcharts , photographs ; _c25cm
502			_aThesis (M.Sc.) - Cairo University - Faculty of Oral and Dental Medicine - Department of Oral Biology
520			_aObjectives: Artificial sweeteners are now abundant in all forms of beverages and food. Aspartame after saccharine is the most widely used artificial sweetener in the world. To substitute aspartame with a safer natural sweetener, some nutritionists believed that fructose is a safer form of sugar. Stevia rebaudiana is a natural herb, having great sweetening power and claimed to be safe for consumption. The current study was performed to investigate and compare the the effect of Fructose and Stevia as natural sweeteners to artificial sweetener (Aspartame) on the integrity of submandibular salivary gland of albino rats. This was achieved in terms of histological, histomorphometric and immunohistochemical analysis of the obtained data. Design: Fifty six male albino rats were utilized, fourteen as stevial group and twenty eight as aspartame and fructose treatment groups. The submandibular glands were dissected and examined histologically, immunohistochemically for NF-mB and p53 as well as histomorphometrically. Results: The histopathological results administration of aspartame, fructose and stevia showed degenerative effects on acini and duct systems Immunohistochemically, the image analysis revealed that the greatest mean values for both area percent and optical density of NF-mB were recorded in group II, whereas the lowest mean in control. ANOVA test revealed that the difference between groups was statistically significant (p<0.0001). Concerning the area percent of p53, the greatest mean value of was recorded in group I, whereas the lowest mean was in control
530			_aIssued also as CD
653		4	_aAspartame
653		4	_aFructose
653		4	_aStevia
700	0		_aMarwa Magdy Saad , _eSupervisor
700	0		_aSamia Mostafa Kamal , _eSupervisor
856			_uhttp://172.23.153.220/th.pdf
905			_aNazla _eRevisor
905			_aSamia _eCataloger
942			_2ddc _cTH
999			_c69402 _d69402