| 000 | 02411cam a2200349 a 4500 | ||
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| 003 | EG-GiCUC | ||
| 005 | 20250223032145.0 | ||
| 008 | 190108s2018 ua dh f m 000 0 eng d | ||
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_aEG-GiCUC _beng _cEG-GiCUC |
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| 041 | 0 | _aeng | |
| 049 | _aDeposite | ||
| 097 | _aPh.D | ||
| 099 | _aCai01.08.09.Ph.D.2018.Ah.P | ||
| 100 | 0 | _aAhmed Fathi Mohamed Ahmed Kamal Eldin | |
| 245 | 1 | 0 |
_aPossible renal protective effects of certain anti-inflammatory and antioxidant compounds in a mouse model of LPS-induced toxicity / _cAhmed Fathi Mohamed Ahmed Kamal Eldin ; Supervised Helmy Moawad Sayed , Hala Fahmy Zaki , Marwa Mohamed Safar |
| 246 | 1 | 5 | _aالتأثيرات الوقائية الكلوية المحتملة لبعض مضادات الالتهاب و مضادات الأكسدة من السمية المستحدثة بواسطة الليبوبوليساكارايد في نموذج الفأر |
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_aCairo : _bAhmed Fathi Mohamed Ahmed Kamal Eldin , _c2018 |
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| 300 |
_a150 P. : _bcharts , facsimiles ; _c25cm |
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| 502 | _aThesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Pharmacology and Toxicology | ||
| 520 | _aThe present study aimed to examine the ability of cilostazol, taurine & telluric acid to alleviate LPS-induced renal dysfunction, inflammation and oxidative stress and compare them to dexamethasone. Kidneys of mice pretreated with the aforementioned agents exhibited amelioration of oxidative stress as manifested by decreased TBARS parallel to increased GSH renal contents, enhanced Nrf2 mRNA expression and HO-1 activity. Attenuated renal inflammation was manifested by a decline of TLR4/ MyD88 gene expression and/or downstream NF-mB and IL-1Ý renal contents. A notable activation of PI3K/Akt signaling was also noted following pretreatment with the tested agents. This was associated with a decrease in serum creatinine and cystatin C levels as well as renal KIM-1 and NGAL contents, in addition to improvement of renal histopathologic insults | ||
| 530 | _aIssued also as CD | ||
| 653 | 4 | _aDexamethasone | |
| 653 | 4 | _aLipopolysaccharide | |
| 653 | 4 | _aOxidative stress | |
| 700 | 0 |
_aHala Fahmy Zaki , _eSupervisor |
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| 700 | 0 |
_aHelmy Moawad Sayed , _eSupervisor |
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| 700 | 0 |
_aMarwa Mohamed Safar , _eSupervisor |
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| 856 | _uhttp://172.23.153.220/th.pdf | ||
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_aEnas _eCataloger |
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| 905 |
_aNazla _eRevisor |
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_2ddc _cTH |
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_c69451 _d69451 |
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