| 000 | 02662cam a2200349 a 4500 | ||
|---|---|---|---|
| 003 | EG-GiCUC | ||
| 005 | 20250223032146.0 | ||
| 008 | 190110s2018 ua dh f m 000 0 eng d | ||
| 040 |
_aEG-GiCUC _beng _cEG-GiCUC |
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| 041 | 0 | _aeng | |
| 049 | _aDeposite | ||
| 097 | _aPh.D | ||
| 099 | _aCai01.08.09.Ph.D.2018.Mo.P | ||
| 100 | 0 | _aMostafa Adel Mohamed Elzuhary Abdelhamed Rabie | |
| 245 | 1 | 4 |
_aThe possible modulatory role of an angiotensin metabolite in a Parkinson model in rats / _cMostafa Adel Mohamed Elzuhary Abdelhamed Rabie ; Supervised Dalaal Moustafa Abdallah , Hanan Salah Eldin Elabhar , Noha Nagah Nassar |
| 246 | 1 | 5 | _aالدور المعدل المحتمل لأحد المنتجات الايضية للانجيوتنسن في نموذج الشلل الرعاش بالجرذان |
| 260 |
_aCairo : _bMostafa Adel Mohamed Elzuhary Abdelhamed Rabie , _c2018 |
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| 300 |
_a172 P. : _bcharts , facsimiles ; _c25cm |
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| 502 | _aThesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Pharmacology and Toxicology | ||
| 520 | _aMAS receptor (MASR), expressed in several brain areas, conferred neuroprotection against neurodegenerative disorders when activated by angiotensin (Ang) 1-7; however, its role in Parkinson{u2019}s disease (PD) remains elusive. Intra-striatal post-administration of Ang 1-7 using a 6-hydroxydopamine (OHDA) PD model improved motor performance and muscle coordination. Ang 1-7 also enhanced substantia nigral tyrosine hydroxylase (TH) immunoreactivity and striatal dopamine content indicating the preservation of the dopaminergic neurons. On the molecular level, Ang 1-7 increased striatal STAT-3 and SOCS3 and MASR mRNA with the upsurge in its downstream targets (p-PI3K/p-Akt/p-CREB/BDNF) to phosphorylate TrKB. This effect extended to inhibit the striatal expression of Ang II type-1 receptor (AT-1R), RAGE, and HMGB-1, in addition to reduction in PARP-1. Ang 1-7 was also able to decrease p-MAPK p38/NF-mB p65/TNF-Ü, as well as NADPH oxidase (Nox) and lipid peroxidation to level the inflammatory and oxidative stress events off. The Ang 1-7-mediated activation of MASR cue and the suppression of the AT-1R cascade were partially reversed by the intrastartial injection of A 779, a MASR antagonist | ||
| 530 | _aIssued also as CD | ||
| 653 | 4 | _aA 779 | |
| 653 | 4 | _aDopamine | |
| 653 | 4 | _aNADPH oxidase | |
| 700 | 0 |
_aDalaal Moustafa Abdallah , _eSupervisor |
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| 700 | 0 |
_aHanan Salah Eldin Elabhar , _eSupervisor |
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| 700 | 0 |
_aNoha Nagah Nassar , _eSupervisor |
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| 856 | _uhttp://172.23.153.220/th.pdf | ||
| 905 |
_aEnas _eCataloger |
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| 905 |
_aNazla _eRevisor |
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| 942 |
_2ddc _cTH |
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| 999 |
_c69485 _d69485 |
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