000			03202cam a2200349 a 4500
003			EG-GiCUC
005			20250223032156.0
008			190129s2018 ua o f m 000 0 eng d
040			_aEG-GiCUC _beng _cEG-GiCUC
041	0		_aeng
049			_aDeposite
097			_aM.Sc
099			_aCai01.12.21.M.Sc.2018.Af.C
100	0		_aAfaf Abdallah Mohamed
245	1	0	_aComparative studies on some novel biomarkers for enhanced detection in patients with hepatocellular carcinoma / _cAfaf Abdallah Mohamed ; Supervised Ibrahim M. A. Elagouza , Mohamed Said Abdelaziz , Muhammad Mostafa Abdelghaffar
246	1	5	_aدراسات مقارنة على بعض المؤشرات الحيوية لتعزيزالكشف المبكر عن المرضى الذين يعانون من سرطان الكبد
260			_aCairo : _bAfaf Abdallah Mohamed , _c2018
300			_a116 P. : _bphotographs ; _c25cm
502			_aThesis (M.Sc.) - Cairo University - Faculty of Science - Department of Zoology
520			_aHepatocellular Carcinoma (HCC) is the fifth most common malignant tumor worldwide. In Egypt, its incidence rate was estimated to be between 5-7 per 100,000 populations per year. Taurine has been demonstrated to functions as a direct and indirect antioxidant and found to display antineoplastic effect through inhibition of angiogenesis and enhancement of tumor cell apoptosis. Its serum level was used as a biomarker in endometrial carcinoma and cancer breast in women. The aim of the study; The current research concerned with measuring serum taurine level in precancerous and cancer patients hoping to use its level as a biomarker in early detection or diagnosis of HCC in Egyptian patients, Patients and methods; Three groups of a total 80 patient{u2019}s candidate were selected from many patients presented with abdominal troubles and signs of liver impairment from Tropical Medicine Department, Ahmed Maher Teaching Hospital. The selected patients were classified into three groups, 1st group, included 20 patients were diagnosed as acute chronic hepatitis, 2nd group, included 20 patients diagnosed as cirrhotic patients. 3rd group: include 40 patients admitted to the hospital for treatment from typical HCC in different histopathological stages, full clinical examinations and imaging techniques (Abdominal Ultra Sound; CAT. Scan; oesophagoscope), fasting blood sample were taken from all patients to measure level of serum of AFP, AFU, and taurine, besides complete biochemical analysis (including liver and kidney functions, complete blood picture, FBS, prothrombin) and virus detection by PCR. Liver cells were examining histopathologically after taking a liver biopsy from all selected patients. Adding to 20 healthy volunteers was also enrolled as control
530			_aIssued also as CD
653		4	_acirrhosis of the liver
653		4	_aliver cancer
653		4	_aTaurine
700	0		_aIbrahim M. A. Elagouza , _eSupervisor
700	0		_aMohamed Said Abdelaziz , _eSupervisor
700	0		_aMuhammad Mostafa Abdelghaffa , _eSupervisor
856			_uhttp://172.23.153.220/th.pdf
905			_aAsmaa _eCataloger
905			_aNazla _eRevisor
942			_2ddc _cTH
999			_c69823 _d69823