| 000 | 02492cam a2200349 a 4500 | ||
|---|---|---|---|
| 003 | EG-GiCUC | ||
| 005 | 20250223032209.0 | ||
| 008 | 190218s2018 ua dh f m 000 0 eng d | ||
| 040 |
_aEG-GiCUC _beng _cEG-GiCUC |
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| 041 | 0 | _aeng | |
| 049 | _aDeposite | ||
| 097 | _aPh.D | ||
| 099 | _aCai01.08.09.Ph.D.2018.Sh.N | ||
| 100 | 0 | _aShimaa Mohamed Azmy Mohamed | |
| 245 | 1 | 0 |
_aNeurobehavioral and neurochemical changes caused by Co-administration of tramadol with other drugs of abuse in experimental animals / _cShimaa Mohamed Azmy Mohamed ; Supervised Eldin Said Eldenshary , Noha Nagah Nassar , Somia Ahmed Nada |
| 246 | 1 | 5 | _aالتغيرات السلوكية العصبية و الكيميائية العصبية التى يسببها التناول المتزامن للترامادول مع أدويه الإدمان الأخرى فى حيوانات التجارب |
| 260 |
_aCairo : _bShimaa Mohamed Azmy Mohamed , _c2018 |
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| 300 |
_a168 P. : _bcharts , facsimiles ; _c25cm |
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| 502 | _aThesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Pharmacology and Toxicology | ||
| 520 | _aNicotine and tramadol concomitant drug dependence pose increasing social, economic as well as public threats. Accordingly, the present study investigated neurochemical, neurobehavioral and neuropathological changes in the brain subsequent to the interaction of nicotine and tramadol. To this end, tramadol (20 mg/kg, i.p) and nicotine (0.25 mg/kg, i.p) were administrated to male albino mice once daily for 30 days. Consequent to microglial activation, nicotine exacerbated oxidative/nitrosative stress induced by tramadol as manifest by the step-up in thiobarbituric acid reactive substances and nitric oxide subsequent to the enhanced levels of neuronal and inducible nitric oxide synthases; paralleled by decreased non-protein sulfhydryls. Increased oxidative stress by tramadol and/or nicotine sequentially augmented nuclear factor kappa B and the proinflammatory cytokine tumor necrosis factor Ü with the induction of apoptosis evident by the increased caspase-3 immunoreactivity | ||
| 530 | _aIssued also as CD | ||
| 653 | 4 | _aDopamine | |
| 653 | 4 | _aNicotine | |
| 653 | 4 | _aTramadol | |
| 700 | 0 |
_aEldin Said Eldenshary , _eSupervisor |
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| 700 | 0 |
_aNoha Nagah Nassar , _eSupervisor |
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| 700 | 0 |
_aSomia Ahmed Nada , _eSupervisor |
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| 856 | _uhttp://172.23.153.220/th.pdf | ||
| 905 |
_aNazla _eRevisor |
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| 905 |
_aSamia _eCataloger |
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| 942 |
_2ddc _cTH |
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| 999 |
_c70274 _d70274 |
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