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040 _aEG-GiCUC
_beng
_cEG-GiCUC
041 0 _aeng
049 _aDeposite
097 _aM.Sc
099 _aCai01.08.09.M.Sc.2018.Ay.S
100 0 _aAya Mohamed Zaki Eid
245 1 0 _aStudy of the possible protective effects of apigenin and plumbagin in hepatic ischemia-reperfusion injury in rats /
_cAya Mohamed Zaki Eid ; Supervised Hala F. Zaki , Rania M. Abdelsalam , Dalia M. Eltanbouly
246 1 5 _aدراسة التأثير الوقائى المحتمل لكل من ابيجينين و بلومباجين منفردين فى فقر الدم الموضعى و اعادة التروية فى كبد الجرذان
260 _aCairo :
_bAya Mohamed Zaki Eid ,
_c2018
300 _a168 P. :
_bcharts , photographs ;
_c25cm
502 _aThesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmacology and Toxicology
520 _aIschemia-reperfusion (I/R) injury is a pathological process which magnifies with the ensuing inflammatory response and endures with the increase of oxidants especially during reperfusion. The present study was conducted to assess the possible modulatory effects of two biologically active constituents of plant origin named apigenin and plumbagin, where the former is the active constituent extracted from the roots of traditional medicinal plant Plumbago zeylanica L and the latter is a flavonoid that exists abundantly in numerous herbs and vegetables, including chamomile, thyme, parsley and broccoli., on the dire role of high mobility group box (HMGB1) as well as the associated inflammation, oxidative stress and apoptotic cell death following hepatic I/R. Six groups of rats were included: sham operated, sham operated treated with apigenin, sham operated treated with plumbagin, I/R (30 min ischemia and 1 h reperfusion) , I/R treated with apigenin and I/R treated with plumbagin. Pretreatment with apigenin and plumbagin markedly improved hepatic function and histology, as indicated by reduced transaminase levels, lactate dehydrogenase activity and ameliorated tissue pathological changes. They significantly reduced high mobility group box 1 (HMGB1) expression and subsequently suppressed inflammatory cascades, as liver NF-mB and TNF-Ü as well as MPO activity. Both were capable of interrupting ROS-HMGB1loop as evident by restored liver GSH, decreased liver lipoperoxidation, and enhanced glutathione peroxidase (GPx) activity. Simultaneously, apoptosis was significantly ameliorated by increasing the Bcl-2/Bax ratio
530 _aIssued also as CD
653 4 _aApigenin
653 4 _aIschemia-reperfusion
653 4 _aLiver
700 0 _aDalia Moustafa Eltanbouly,
_eSupervisor
700 0 _aHala Fahmy Zaki ,
_eSupervisor
700 0 _aRania Mohsen Abdelsalam ,
_eSupervisor
856 _uhttp://172.23.153.220/th.pdf
905 _aNazla
_eRevisor
905 _aSamia
_eCataloger
942 _2ddc
_cTH
999 _c70283
_d70283