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040 _aEG-GiCUC
_beng
_cEG-GiCUC
041 0 _aeng
049 _aDeposite
097 _aPh.D
099 _aCai01.11.16.Ph.D.2018.Am.H
100 0 _aAmal Ahmed Farag
245 1 0 _aHistological and Immuno-histochemical study on the possible effect of vitamin K2 on the hepatic oval cells in diabetic and non-diabetic albino rats /
_cAmal Ahmed Farag ; Supervised Zakaria Abdalhamid Edris , Dalia Mohamed Elmarakby , Abeer Ibrahim Abdallah
246 1 5 _aدراسه هستولوجيه و هستوكيميائية مناعيه على التاثير المحتمل لفيتامين ك2 على الخلايا البيضاويه الكبديه فى الجرذان البيضاء المصابه و العير مصابه بداء السكرى
260 _aCairo :
_bAmal Ahmed Farag ,
_c2018
300 _a164 P. :
_bfacsimiles ;
_c25cm
502 _aThesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Histology
520 _aBackground: Diabetes is a group of metabolic diseases characterized by hyperglycemia resulting from defects in insulin secretion, insulin action, or both. The regeneration of beta cells from embryonic or adult stem cells or pancreatic progenitor cells is an attractive method for diabetic treatment. Hepatic oval cell (HOC) is an intra-hepatic population of bipotent progenitor cells, which have the ability to proliferate and differentiate into both mature hepatocytes and bile duct epithelial cells. Hepatic oval cells are thought to have the potential to transdifferentiate into pancreatic endocrine cells, as both the liver and the pancreas originate from appendages of the upper primitive foregut endoderm. Vitamin K2 is believed to promote liver functional recovery in patients with liver cirrhosis as well as improving insulin sensitivity and glucose tolerance, preventing insulin resistance, and reducing the risk of type 2 diabetes. Aim of the work: To evaluate the histological and immunohistochemical changes in the hepatic and oval cells in the liver of diabetic rats under treatment with vitamin K2
530 _aIssued also as CD
653 4 _aDiabetes
653 4 _aDiabetic rats
653 4 _aHepatic oval cells
700 0 _aAbeer Ibrahim Abdallah ,
_eSupervisor
700 0 _aDalia Mohamed Elmarakby ,
_eSupervisor
700 0 _aZakaria Abdalhamid Edris ,
_eSupervisor
856 _uhttp://172.23.153.220/th.pdf
905 _aNazla
_eRevisor
905 _aSamia
_eCataloger
942 _2ddc
_cTH
999 _c70784
_d70784