000			02988cam a2200349 a 4500
003			EG-GiCUC
005			20250223032225.0
008			190313s2018 ua dh f m 000 0 eng d
040			_aEG-GiCUC _beng _cEG-GiCUC
041	0		_aeng
049			_aDeposite
097			_aPh.D
099			_aCai01.11.29.Ph.D.2018.Mo.C
100	0		_aMohammed Hassan Gad
245	1	0	_aComparative study between sitagliptin and donepezil on experimentally-induced alzheimer{u2019}s disease in rats / _cMohammed Hassan Gad ; Supervised Amal Anwar Mishriki , Eman Abdelmonem Abdelrasheed , Afaf Sayed Osman
246	1	5	_aمقارنة بين السيتاجليبتين والدونيبيزيل في مرض الزهايمر المحدث تجريبيا في الجرذان
260			_aCairo : _bMohammed Hassan Gad , _c2018
300			_a141 P. : _bcharts , facsimiles ; _c25cm
502			_aThesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Pharmacology
520			_aIntroduction: The aim of this study is to investigate the possible role of sitagliptin on improving memory defects in Alzheimer's disease in rats.This was performed by comparing sitagliptin withdonepezil in both diabetic and non-diabetic models of Alzheimer'sdisease.Material and methods: Eightyadult female albino rats, matched for age and weight (between 150 and 230 g) were used for the experiment. The rats were divided into main 4 groups:Group (1) untreated rats were left to the end of the experiment.Group (2) Sitagliptin 10 mg/kg was given orally by gavage. Group (3) Alzheimer model was done by intrapertonial injection of aluminum chloride that was dissolved in water and injected to rats in a dose of 4.2mg/kg for 28 days and subdivided into 3 groups.Group (3a) after intrapertonial injection of aluminum chloride, rats were left untreated.Group (3b) sitagliptin 10 mg/kg was given orally for 2 weeks after starting aluminum chloride injection and was used for 28 days. Group (3c) donepezil 1 mg/kg was given orally 2 weeks after starting aluminum chloride injection and was used for 28 days. Group (4) diabetes mellitus was induced by a single intraperitoneal injection of freshly dissolved streptozotocin (STZ) 60 mg/kg to 18 h fasted rats. Animals with fasting blood glucose above 200 mg/dl were included in the study as diabetics and subdivided into 3 groups.Group (4a) rats were left untreated.Group (4b) sitagliptin 10 mg/kg was given orally to diabetic rats and was used for 28 days. Group (4c) donepezil 1 mg/kg was given orally to diabetic rats and was used for 28 days
530			_aIssued also as CD
653		4	_aMemory changes
653		4	_aMorris water maz test
653		4	_aSitagliptin
700	0		_aAfaf Sayed Osman , _eSupervisor
700	0		_aAmal Anwar Mishriki , _eSupervisor
700	0		_aEman Abdelmonem Abdelrasheed , _eSupervisor
856			_uhttp://172.23.153.220/th.pdf
905			_aNazla _eRevisor
905			_aShimaa _eCataloger
942			_2ddc _cTH
999			_c70806 _d70806