| 000 | 02970cam a2200349 a 4500 | ||
|---|---|---|---|
| 003 | EG-GiCUC | ||
| 005 | 20250223032245.0 | ||
| 008 | 180415s2018 ua dh f m 000 0 eng d | ||
| 040 |
_aEG-GiCUC _beng _cEG-GiCUC |
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| 041 | 0 | _aeng | |
| 049 | _aDeposite | ||
| 097 | _aM.Sc | ||
| 099 | _aCai01.24.03.M.Sc.2018.Ab.P | ||
| 100 | 0 | _aAbdullah Ibrahim Elkholy | |
| 245 | 1 | 0 |
_aPharmaceutical study of resveratrol alone and combined with photothermal effect of gold nanoparticles / _cAbdullah Ibrahim Elkholy ; Supervised Maha Fadel Mohamed , Kawser Nazmi Kassab , Tareq Youssef |
| 246 | 1 | 5 | _aدراسة صيدلانية لعقار الريزفيراترول منفردا ومقترنا مع التأ ثير الضوئي الحراري لجسيمات الّذهب النانوية |
| 260 |
_aCairo : _bAbdullah Ibrahim Elkholy , _c2018 |
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| 300 |
_a83 P. : _bcharts , facsimiles ; _c25cm |
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| 502 | _aThesis (M.Sc.) - Cairo University - National Institute of Laser Enhanced Sciences - Department of Laser Applications in Medical Biological | ||
| 520 | _aThis work basically studies the effect of gold nanoparticles, as a drug delivery and photothermally active system, on the cytotoxicity of resveratrol, a natural polyphenol produced by several plants. Gold nanoparticles used for loading were synthesized by the direct reaction between resveratrol itself, as a reducing agent, and chloroauric acid in aqueous medium. Surface plasmon resonance (SPR) and average diameter of the synthesized resveratrol-mediated gold nanoparticles (R*AuNPs) was at 533 nm and ~17 nm respectively. Transmission Electron Microscopy (TEM) imaging showed that the majority of R*AuNPs were spherical or semi-spherical in shape with a distinct coat obviously observed around each particle. Coating material of R*AuNSs was isolated and analyzed using mass spectrometry and FT-IR spectrometry that revealed its polymeric or oligomeric nature meaning that resveratrol underwent oxidative polymerization during the synthesis process.Resveratrol, as a chemotherapeutic agent, was then loaded onto R*AuNSs, using Tween-20 as a linker, with loading capacity up to 11.6 % w/w. R*AuNSs and Resveratrol loaded R*AuNSs (R-R*AuNSs) showed good stability in aqueous media. Release of resveratrol from R*AuNSs in vitro was found to follow zero order kinetics with initial burst release. Cytotoxicity of free and loaded resveratrol (R and R-R*AuNSs) as well as free gold nanospheres (R*AuNSs) was examined under both dark and irradiation conditions using HepG2 cells as a model for cancer cells | ||
| 530 | _aIssued also as CD | ||
| 653 | 4 | _aGold nanoparticles | |
| 653 | 4 | _aPhotothermal | |
| 653 | 4 | _aResveratrol | |
| 700 | 0 |
_aKawser Nazmi Kassab , _eSupervisor |
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| 700 | 0 |
_aMaha Fadel Mohamed , _eSupervisor |
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| 700 | 0 |
_aTareq Youssef , _eSupervisor |
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| 856 | _uhttp://172.23.153.220/th.pdf | ||
| 905 |
_aNazla _eRevisor |
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| 905 |
_aShimaa _eCataloger |
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| 942 |
_2ddc _cTH |
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| 999 |
_c71474 _d71474 |
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