000			02835cam a2200337 a 4500
003			EG-GiCUC
005			20250223032248.0
008			190420s2018 ua f m 000 0 eng d
040			_aEG-GiCUC _beng _cEG-GiCUC
041	0		_aeng
049			_aDeposite
097			_aM.Sc
099			_aCai01.12.10.M.Sc.2018.Zi.S
100	0		_aZinab Atwa Saad Atwa Elnaggar
245	1	0	_aSynthesis of some new heterocyclic compounds with expected biological activity from cyanoacetamide derivatives / _cZinab Atwa Saad Atwa Elnaggar ; Supervised Hussein Fouad Zohdi , Ibrahim Adel Ibrahim Eldosoky
246	1	5	_aتشييد بعض المركبات الغير متجانسة الحلقة الجديدة و المتوقع لها نشاط بيولوجى من مشتقات سيانو أسيتاميد
260			_aCairo : _bZinab Atwa Saad Atwa Elnaggar , _c2018
300			_a113 P. ; _c25cm
502			_aThesis (M.Sc.) - Cairo University - Faculty of Science - Department of Organic Chemistry
520			_aThe original work of this thesis includes: A series of arylidene derivatives 4a-l, 2-imino-chromene derivatives 6a-e and aryl hydrazones derivates 8a-d were synthesized via the reaction of 2-cyano-N-(1,3-dihydroxy-2-(hydroxylmethyl) propan-2-yl) acetamide 2 with aldehydes and aryldiazonium salts. Refluxing cyanoacetamide derivative 2 with phenyl isothiocyanate and elemental sulfur afforded 4-amino-N-(1,3-dihydroxy-2-(hydroxymethyl) propan-2-yl)-3-phenyl-2- thioxo-2, 3-5-carboxamide 9. Also, reaction of 2 with cyclopentanone or cyclohexanone and elemental sulfur gave the corresponding aminothiophene derivatives 10. Treatment of cyanoacetamide derivative 2 with pentane-2,4-dione provided aminothiophene derivative 11. Condensation of enaminonitrile derivative 12 with 4-(phenyldiazenyl)-1H- pyrazole-3, 5-diamine derivatives 13a-e furnished pyrazolo [1,5-a] pyrimidine derivatives 14a-e. Refluxing of 12 with cyanoguanidine and guanidine nitrate produced 2,4-diimino-1,2,3,4-tetrahydropyrimidine-5-carboxamides 15 and 16 respectivly. Also, grinding enaminonitrile 12 with hydrazine hydrate provided 3-amino-N-(1,3-dihydroxy-2-(hydroxymethyl) propan-2-yl)-1H-pyrazole-4-carboxamide 17. The newly synthesized compounds were proved by elemental and spectral data. All plausible mechanisms for their formation were discussed. Some of the selected products were tested and evaluated as antimicrobial agents
530			_aIssued also as CD
653		4	_a 2-cyano-N-(1,3-dihydroxy-2-(hydroxy methyl) propan-2-yl)acetamide
653		4	_a2-imino-chromenes
653		4	_aArylidenes
700	0		_aHussein Fouad Zohdi , _eSupervisor
700	0		_aIbrahim Adel Ibrahim Eldosoky , _eSupervisor
856			_uhttp://172.23.153.220/th.pdf
905			_aNazla _eRevisor
905			_aSamia _eCataloger
942			_2ddc _cTH
999			_c71569 _d71569