| 000 | 02633cam a2200337 a 4500 | ||
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| 003 | EG-GiCUC | ||
| 005 | 20250223032251.0 | ||
| 008 | 190424s2018 ua dh f m 000 0 eng d | ||
| 040 |
_aEG-GiCUC _beng _cEG-GiCUC |
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| 041 | 0 | _aeng | |
| 049 | _aDeposite | ||
| 097 | _aM.Sc | ||
| 099 | _aCai01.12.21.M.Sc.2018.Ah.E | ||
| 100 | 0 | _aAhmed Salih Ahmed Elfaky | |
| 245 | 1 | 0 |
_aEvaluating the safety and anticancer activity of artemisia herba alba extract compared to the semi-synthetic derivative artesunate in ehrlich solid carcinoma bearing mice / _cAhmed Salih Ahmed Elfaky ; Supervised Mahmoud Ahmed Amer , Hanan Ramadan Hamad |
| 246 | 1 | 5 | _aتقييم السلامة و النشاط المضاد للسرطان لمستخلص الأرتميسيا هربا ألبا مقارنة بالمشتق شبه الصناعي: أرتيسونيت في الفئران الحاملة لسرطان ايرليش الصلب |
| 260 |
_aCairo : _bAhmed Salih Ahmed Elfaky , _c2018 |
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| 300 |
_a104 P. : _bcharts , facsimiles ; _c25cm |
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| 502 | _aThesis (M.Sc.) - Cairo University - Faculty of Science - Department of Zoology (Physiology Immunology) | ||
| 520 | _aThe search for new anticancer drugs targeted cancer cells selectivelywithout side effects is an important task because of various side effects caused bychemotherapeutic drugs.Thus, our study was performed to assess the safety andanticancer activity of the Artemisia herbaalbaextract compared to the semisyntheticdrug Artesunatein mice. The oral administration of Artemisia herbaalbacaused single and double stranded DNA breaks leading to apoptosis of tumor cellsas revealed by the smeared pattern of genomic DNA through elevations of p53expression levels in conjunction with decreasing K-ras expression levels in a timedependent manner similar to Artesunateand better than Cisplatin. The apoptosis oftumor cells was further confirmed by the appearance of apoptotic and necrotictumor cells as well as the infiltrations of mononuclear cells into the tumor sectionsof the treated groups.Minor histological lesions were observed in the liver andkidney tissues sections of Artemisia extract group compared to the high histologicallesions observed in the liver and kidney tissues of Artesunateand Cisplatin groups | ||
| 530 | _aIssued also as CD | ||
| 653 | 4 | _aAnticancer efficacy | |
| 653 | 4 | _aArtemisia herbaalba | |
| 653 | 4 | _aArtesunate | |
| 700 | 0 |
_aHanan Ramadan Hamad , _eSupervisor |
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| 700 | 0 |
_aMahmoud Ahmed Amer , _eSupervisor |
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| 856 | _uhttp://172.23.153.220/th.pdf | ||
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_aNazla _eRevisor |
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| 905 |
_aShimaa _eCataloger |
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| 942 |
_2ddc _cTH |
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_c71690 _d71690 |
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