| 000 | 02528cam a2200337 a 4500 | ||
|---|---|---|---|
| 003 | EG-GiCUC | ||
| 005 | 20250223032303.0 | ||
| 008 | 190519s2018 ua dh f m 000 0 eng d | ||
| 040 |
_aEG-GiCUC _beng _cEG-GiCUC |
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| 041 | 0 | _aeng | |
| 049 | _aDeposite | ||
| 097 | _aM.Sc | ||
| 099 | _aCai01.08.09.M.Sc.2018.He.N | ||
| 100 | 0 | _aHeba Nasr Mohamed Moustafa | |
| 245 | 1 | 0 |
_aNeuroprotective evaluation of certain antiepileptic drugs on 3-nitropropionic acid-induced neurotoxicity in rat / _cHeba Nasr Mohamed Moustafa ; Supervised Hala Fahmy Zaki , Dalia Moustafa Eltanbouly |
| 246 | 1 | 5 | _aتقييم فعالية بعض الأدوية المضادة للصرع فى الوقاية من التسمم العصبى المحدث بواسطة حمض 3-نيترو بروبيونيك فى الجرذان |
| 260 |
_aCairo : _bHeba Nasr Mohamed Moustafa , _c2018 |
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| 300 |
_a146 P. : _bcharts , facsimiles ; _c25cm |
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| 502 | _aThesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmacology and Toxicology | ||
| 520 | _aPrevalence of glutamate receptor subunit 2 (GluR2)-lacking Ü-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptors is a hallmark of excitotoxicity-related neurodegenerative diseases. Topiramate (TOP) is a structurally novel anticonvulsant with a well-known modulatory effect on AMPA/kainate subtypes of glutamate receptors. Levetiracetam (LEV) is a unique anti-epileptic acting mainly via inhibition of glutamate release. The present study aimed at investigating the neuroprotective potentials of TOP and LEV on 3-nitropropionic acid (3-NP)-induced striatal neurodegeneration and Huntington's disease (HD)-like symptoms. Rats were injected with 3-NP (10 mg/kg/i.p.) for 14 days, TOP (50 mg/kg/p.o.) and LEV (100mg/ kg/p.o.) were given once a day, 1 h before 3-NP. Administration of TOP and LEV amended 3-NP induced changes in neurobehavioral performance, striatal neurotransmitters levels and histopathological injury. 3-NP control rats showed a significant ablation in the mRNA expression of Ca2+-impermeable Glu2R subunit along with an elevation in its regulatory protein PICK1, an effect that was largely reversed by TOP and LEV | ||
| 530 | _aIssued also as CD | ||
| 653 | 4 | _aAMPA | |
| 653 | 4 | _aGluR2 | |
| 653 | 4 | _aGlutamate | |
| 700 | 0 |
_aDalia Moustafa Eltanboul , _eSupervisor |
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| 700 | 0 |
_aHala Fahmy Zaki , _eSupervisor |
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| 856 | _uhttp://172.23.153.220/th.pdf | ||
| 905 |
_aNazla _eRevisor |
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| 905 |
_aSamia _eCataloger |
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| 942 |
_2ddc _cTH |
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| 999 |
_c72031 _d72031 |
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