000			02840cam a2200325 a 4500
003			EG-GiCUC
008			190523s2018 ua o f m 000 0 eng d
040			_aEG-GiCUC _beng _cEG-GiCUC
041	0		_aeng
049			_aDeposite
097			_aPh.D
099			_aCai01.10.02.Ph.D.2018.Em.E
100	0		_aEman Hany Hassan Abdelnaby
245	1	0	_aEffect of antioxidants on behavioural, biochemical and histopathological modifications - neuroinflammation, neurodegeneration in alzheimer's disease rat model / _cEman Hany Hassan Abdelnaby ; Supervised Mervat Mahmoud Kamel , Heba Said Ellethey , Kassem Gabr Aliraqi
246	1	5	_aتأثير مضادات الأكسدة على التغيرات السلوكية و البيوكيميائية و الهيستوباثولوجية (الالتهاب و التدمير العصبى) في نموذج الجرذان لمرض الزهايمر
260			_aCairo : _bEman Hany Hassan Abdelnaby , _c2018
300			_a138 P. : _bphotographs ; _c25cm
502			_aThesis (Ph.D.) - Cairo University - Faculty of Veterinary Medicine - Department of Animal Behavior and Management
520			_aThe present study was designed to evaluate the ameliorating and protective effect of caffeine (CF), Chia extract (CH) and Lepidium Sativum extract (LS) on aluminum chloride (AlCl3) induced AD rat model. 128 adult Wistar male rats were allocated into 8 groups of 16 animals each, where control group (C) was supplied with normal tap water, while AD group was administered AlCl3 in drinking water at 200 mg/kg body weight. AD ameliorated groups with caffeine (CF-AD), chia (AD-CH) and LS (AD-LS) were exposed to AlCl3 alternatively with the ameliorating treatments in a day after day regime, while in CF, CH and LS groups rats were administered the different treatments alternatively with plan water. All groups received their respective treatments for 4 months after which behavioural analysis was performed including open field test (OFT) and elevated plus maze to assess anxiety-like behaviours, Y- maze test and novel object recognition test (NOR) to assess memory and learning abilities and forced swim test (FST) to evaluate the depression-like behaviour. After monitoring the behavioural activities, rats were decapitated, and their brains and hippocampus samples were collected for analysis of oxidative status (SOD, GSH, GSSG, MDA, 8OHdG, NO), metabolic dysfunction (ATP, PC, PS) and neurochemical profile (DA, DOPAC, HVA, 5-HT, 5-HIAA)
530			_aIssued also as CD
653		4	_aAlzheimer's disease
653		4	_aAntioxidants
653		4	_aChia seeds
700	0		_aHeba Said Ellethey , _eSupervisor
700	0		_aKassem Gabr Aliraqi , _eSupervisor
700	0		_aMervat Mahmoud Kamel , _eSupervisor
905			_aNazla _eRevisor
905			_aSamia _eCataloger
942			_2ddc _cTH
999			_c72146 _d72146