| 000 | 02745cam a2200349 a 4500 | ||
|---|---|---|---|
| 003 | EG-GiCUC | ||
| 005 | 20250223032313.0 | ||
| 008 | 190613s2018 ua dh f m 000 0 eng d | ||
| 040 |
_aEG-GiCUC _beng _cEG-GiCUC |
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| 041 | 0 | _aeng | |
| 049 | _aDeposite | ||
| 097 | _aPh.D | ||
| 099 | _aCai01.08.09.Ph.D.2018.Sh.S | ||
| 100 | 0 | _aShereen Nader Elsayed Hussein Raafat | |
| 245 | 1 | 0 |
_aStudy of the possible effects of statins and platelet rich fibrin on bone regeneration in induced bony defects in rats / _cShereen Nader Elsayed Hussein Raafat ; Supervised Mahmoud M. Khattab , Aiman Saad Nasr Eldin Elkhatib , Mohamed Mohey Eldin Elmazar |
| 246 | 1 | 5 | _aدراسة تأثير مركبات الستاتين والصفائح الغنية بالفيبرين فى تجديد عيوب العظام المستحدثة للجرذان |
| 260 |
_aCairo : _bShereen Nader Elsayed Hussein Raafat , _c2018 |
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| 300 |
_a145 P. : _bcharts , facsimiles ; _c25cm |
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| 502 | _aThesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Pharmacology and Toxicology | ||
| 520 | _aStatins like simvastatin (SIM) have demonstrated to have pleiotropic actions other than their conventional use as antilipidemic drugs. Also, nowadays natural scaffolds like platelets rich fibrin (PRF) showed promising results on bone regeneration. Aim This study compares the regenerative power of SIM and PRF added locally each as a sole filling material on induced bone defect and evaluate the combined effect using PRF loaded with SIM. Materials and methods: A critical size bone defect was induced in 48 male albino rats of average weight150{u2013}200 g and were divided into 4 groups according to the filling material. Control, PRF, SIM, and SIM/PRF group. Each group was subdivided according to the sacrificing period into two subgroups (one and two-months postoperatively).Bone mineral density (BMD) at the bone defect area was analyzed using digital X-ray one and two-months postoperatively.Tibial specimens were evaluated histologically using massontrichrome (MT) special stain to detect areas of new bone formation, immunohistochemically using anti- BMP2 and anti-VEGF, serum levels of Osteoprotegerin (OPG), RANKL, osteocalcin and alkaline phosphatase enzyme (ALP) were measured one and two months postoperatively using ELISA | ||
| 530 | _aIssued also as CD | ||
| 653 | 4 | _aBone regeneration | |
| 653 | 4 | _aPRF | |
| 653 | 4 | _aSimvastatin | |
| 700 | 0 |
_aAiman Saad Nasr Eldin Elkhatib , _eSupervisor |
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| 700 | 0 |
_aMahmoud M. Khattab , _eSupervisor |
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| 700 | 0 |
_aMohamed Mohey Eldin Elmazar , _eSupervisor |
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| 856 | _uhttp://172.23.153.220/th.pdf | ||
| 905 |
_aNazla _eRevisor |
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| 905 |
_aShimaa _eCataloger |
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| 942 |
_2ddc _cTH |
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| 999 |
_c72370 _d72370 |
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